{"id":"W3049374360","doi":"10.1161/circgen.120.002919","title":"Polygenic Contribution to Low-Density Lipoprotein Cholesterol Levels and Cardiovascular Risk in Monogenic Familial Hypercholesterolemia","year":2020,"lang":"en","type":"article","venue":"Circulation Genomic and Precision Medicine","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; St. Paul's Hospital; Montreal Clinical Research Institute; McGill University; University of British Columbia","funders":"Medical Research Council","keywords":"Medicine; Internal medicine; Familial hypercholesterolemia; Hazard ratio; Cohort; Atherosclerotic cardiovascular disease; Myocardial infarction; Biobank; PCSK9; Framingham Risk Score; Proportional hazards model; Cardiology; Cholesterol; Endocrinology; Lipoprotein; Disease; LDL receptor; Confidence interval; Bioinformatics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006663179,0.0009024772,0.001787723,0.001439878,0.0005235329,0.001214526,0.0008874777,0.001144642,0.001483447],"category_scores_gemma":[0.009781206,0.0005578689,0.007066277,0.002212764,0.0008017783,0.0004329298,0.0008105059,0.001054951,0.0001077692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006777326,"about_ca_system_score_gemma":0.0007390432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01387253,"about_ca_topic_score_gemma":0.01311483,"domain_scores_codex":[0.9958661,0.002484684,0.0003730078,0.0008004724,0.0003028208,0.0001729827],"domain_scores_gemma":[0.9904608,0.006861591,0.001219824,0.0008176551,0.0004023941,0.0002376889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005962932,0.00009582033,0.7357276,0.002847919,0.2271735,0.0005698009,0.0001959812,0.005531094,0.001356041,0.000845634,0.000725183,0.01896844],"study_design_scores_gemma":[0.0008943808,0.0005229408,0.7420385,0.0008824887,0.2407386,0.00087491,0.00009480954,0.008331353,0.0004507973,0.003537463,0.001574424,0.00005923164],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.827,0.161778,0.006598998,0.001555773,0.000211878,0.00007797142,0.001354307,0.00009500318,0.001328042],"genre_scores_gemma":[0.9930295,0.005513919,0.0007188834,0.0001749418,0.00007092754,0.00002906206,0.0003312959,0.000006552793,0.0001250475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01387253,"threshold_uncertainty_score":0.03523862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02382252653387653,"score_gpt":0.2545294637450882,"score_spread":0.2307069372112117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}