{"id":"W3049465296","doi":"10.1200/jco.20.00522","title":"Switch Control Inhibition of KIT and PDGFRA in Patients With Advanced Gastrointestinal Stromal Tumor: A Phase I Study of Ripretinib","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Gastrointestinal Tumor Research and Treatment","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Foundation Medicine; Genentech; U.S. Food and Drug Administration; Plexxikon; Sirtex Medical; Toray Industries; Springworks Therapeutics; Syndax Pharmaceuticals; BeiGene; Arog Pharmaceuticals; Agios Pharmaceuticals; Ipsen; Array BioPharma; Jazz Pharmaceuticals; Five Prime Therapeutics; Astex Pharmaceuticals; MacroGenics; Celldex Therapeutics; GlaxoSmithKline; IFM Therapeutics; American Society of Clinical Oncology; Valeant Pharmaceuticals International; Eli Lilly and Company; National Comprehensive Cancer Network; Iterion Therapeutics; Halozyme; Revolution Medicines; Karyopharm Therapeutics; Exelixis; Endocyte; Daiichi Sankyo Europe; National Cancer Institute; Calithera Biosciences; Gilead Sciences; Astellas Pharma; Eisai; FibroGen; Celgene; Bristol-Myers Squibb; Deciphera Pharmaceuticals; Amgen; Symphogen; Pfizer; PharmaMar; U.S. Department of Veterans Affairs","keywords":"Medicine; GiST; Internal medicine; Adverse effect; Nausea; Gastroenterology; Constipation; PDGFRA; Imatinib mesylate; Rash; Phases of clinical research; Oncology; Imatinib; Clinical trial; Stromal cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009178155,0.000135682,0.001437558,0.0001164929,0.00001287153,0.000002967464,0.00006875324,0.00003411394,0.00003444977],"category_scores_gemma":[0.004263225,0.00008956927,0.0001268498,0.000155501,0.0001996079,0.00008356328,0.00003680978,0.0007100176,9.172614e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005473472,"about_ca_system_score_gemma":0.000568637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002018782,"about_ca_topic_score_gemma":0.00001952217,"domain_scores_codex":[0.9968094,0.0003568934,0.001914322,0.00018851,0.0005135686,0.0002172742],"domain_scores_gemma":[0.9962184,0.0009397927,0.001576764,0.00009964276,0.0006745253,0.0004908688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.07963025,0.01766266,0.8913789,0.00006027203,0.0001174957,0.002045691,0.0001108435,0.00002351743,0.0007509784,0.000004263563,0.0000226727,0.008192454],"study_design_scores_gemma":[0.08892118,0.3150293,0.5946473,0.0003104496,0.0001524004,0.0002811432,0.0004192012,0.0001225283,0.00006169221,0.00001119165,0.00001001844,0.00003355863],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979898,0.00002752837,0.0001676136,0.001036008,0.00002340879,0.0006587585,0.00001236793,0.000003371627,0.00008116454],"genre_scores_gemma":[0.9951504,0.000004218228,0.004575667,0.0001705379,0.00007920687,0.000004967737,0.00000261526,0.00001077751,0.00000156424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2973666,"threshold_uncertainty_score":0.5103786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06473184962436974,"score_gpt":0.4269756399044538,"score_spread":0.3622437902800841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}