{"id":"W3049509200","doi":"10.2217/epi-2019-0340","title":"The Relationship Between Colorectal Cancer Risk Factors and LINE-1 DNA Methylation in Healthy Colon Tissue","year":2020,"lang":"en","type":"article","venue":"Epigenomics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"DNA methylation; Colorectal cancer; Methylation; Epigenetics; Biology; Oncology; Internal medicine; Population; Cancer; Colonoscopy; Cancer research; Bioinformatics; DNA; Genetics; Medicine; Gene; Gene expression; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003208599,0.000118708,0.0001270509,0.00002405762,0.0002172105,0.00003166762,0.00009426997,0.0001557545,0.000002261325],"category_scores_gemma":[0.0005065659,0.00009892294,0.00002936184,0.0001133447,0.00005366267,0.000004165066,0.00005784605,0.0001588872,0.000002850496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003531187,"about_ca_system_score_gemma":0.00007917211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002179883,"about_ca_topic_score_gemma":0.0008935406,"domain_scores_codex":[0.9990689,0.0001563386,0.000261798,0.0002594661,0.00007475177,0.0001788142],"domain_scores_gemma":[0.999352,0.0002573439,0.0001452702,0.000109519,0.00003404541,0.0001018716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001120077,0.000006266262,0.9477313,0.000007219612,0.00001498632,2.059646e-7,0.0004408841,0.0005795457,0.04675212,0.0000659398,0.00001749793,0.004271999],"study_design_scores_gemma":[0.0003254163,0.0004003161,0.8511899,0.000002497567,0.00001719382,6.608869e-8,0.00007445473,0.0002387861,0.1381347,0.0004861253,0.008999426,0.0001311143],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931265,0.004155142,0.001230319,0.0009833167,0.00009809873,0.0002806766,0.00006394463,0.000007817393,0.00005426129],"genre_scores_gemma":[0.9967877,0.002483154,0.0002111563,0.00005377177,0.0002871874,0.00001650257,0.0001214941,0.00001942855,0.00001963673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0965414,"threshold_uncertainty_score":0.403396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03844530373417284,"score_gpt":0.3114475668558527,"score_spread":0.2730022631216799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}