{"id":"W3049610467","doi":"10.1523/jneurosci.1128-20.2020","title":"<i>Chrna5</i> is Essential for a Rapid and Protected Response to Optogenetic Release of Endogenous Acetylcholine in Prefrontal Cortex","year":2020,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; University of Toronto","keywords":"Optogenetics; Cholinergic; Neuroscience; Nicotinic agonist; Acetylcholine; Postsynaptic potential; Biology; Chemistry; Receptor; Pharmacology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003907949,0.0001295933,0.0002573135,0.00008026705,0.00004171542,0.00001633727,0.0003305211,0.00005880861,0.000003136929],"category_scores_gemma":[0.001450823,0.0001168825,0.0000889431,0.0002782299,0.0001038693,0.000009766733,0.0001639136,0.0001338326,3.92443e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001151533,"about_ca_system_score_gemma":0.0002335657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003165968,"about_ca_topic_score_gemma":0.000002217073,"domain_scores_codex":[0.9986182,0.0001235185,0.0004934392,0.0003107731,0.0002352721,0.000218841],"domain_scores_gemma":[0.9991252,0.00003376178,0.0003134994,0.0001563492,0.0001532003,0.0002180247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003503796,0.0001213017,0.0003386395,0.00002160979,0.000005575298,0.000004727953,0.0002894876,0.00008341759,0.9946682,3.217821e-7,0.0002047197,0.0007581682],"study_design_scores_gemma":[0.002108441,0.004508279,0.006001489,0.00002461533,0.00001554239,0.0002025513,0.00005674537,0.0002647087,0.9810567,0.000001549131,0.005634717,0.0001246291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954612,0.000372465,0.002305483,0.001133815,0.0001279451,0.0005553289,0.00003448579,0.000002461648,0.000006860062],"genre_scores_gemma":[0.9961802,0.0001878008,0.002310745,0.001141241,0.0001326223,0.0000101729,7.417825e-7,0.00001589476,0.00002052447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0136115,"threshold_uncertainty_score":0.4766331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02375831578920415,"score_gpt":0.2771718274324199,"score_spread":0.2534135116432157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}