{"id":"W3049611856","doi":"10.1101/2020.07.15.20154237","title":"Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer’s Disease Neuroimaging Initiative","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"National Institute on Aging; Instituto de Salud Carlos III; Fonds de Recherche du Québec - Santé; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; IXICO; H. Lundbeck A/S; Servier; Orionin Tutkimussäätiö; Eisai; Northern California Institute for Research and Education; Ministerio de Ciencia, Innovación y Universidades; Alzheimerfonden; Weston Brain Institute; Pfizer; Biogen; BioClinica; European Commission; Hjärnfonden; F. Hoffmann-La Roche; University of Southern California; Gun och Bertil Stohnes Stiftelse; Consortium canadien en neurodégénérescence associée au vieillissement; Bristol-Myers Squibb; U.S. Department of Defense; Eli Lilly and Company; BrightFocus Foundation; Emil Aaltosen Säätiö; Demensförbundet; Novartis Pharmaceuticals Corporation; Meso Scale Diagnostics; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Dementia; Alzheimer's Disease Neuroimaging Initiative; Neuroimaging; Medicine; Biomarker; Cognitive decline; Cerebrospinal fluid; Internal medicine; Positron emission tomography; Oncology; Disease; Alzheimer's disease; Pathology; Psychology; Psychiatry; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002624668,0.0007114327,0.0006335546,0.00175315,0.0004929058,0.001103644,0.000858521,0.001019904,0.0008947529],"category_scores_gemma":[0.006096848,0.0003005894,0.0005693742,0.0005909689,0.0002994293,0.0009398628,0.0009306432,0.0006920033,0.0005629961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000378895,"about_ca_system_score_gemma":0.0002197691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003459029,"about_ca_topic_score_gemma":0.003307629,"domain_scores_codex":[0.9990085,0.0003258961,0.0001205632,0.0002616093,0.0001841508,0.00009936152],"domain_scores_gemma":[0.997375,0.0005191285,0.0009459291,0.0001431813,0.0006125253,0.0004041474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006462669,0.0001004012,0.9946498,0.00001716343,0.0001264128,0.0000685846,0.00006288876,0.0002198188,0.000478802,0.00002281807,0.0003233507,0.003283634],"study_design_scores_gemma":[0.00002794752,0.0002577549,0.9947247,0.00001554619,0.00006789852,0.000467451,0.0001081823,0.003386522,0.000533343,0.00008698088,0.0003125367,0.00001113163],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979897,0.0004913216,0.0002669207,0.000060243,0.00002388664,0.00002389826,0.000401281,0.0000235626,0.0007191591],"genre_scores_gemma":[0.998737,0.00009483693,0.0003711833,0.00002537354,0.00001767759,0.00001474191,0.0005442382,0.000004785687,0.0001901512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003459029,"threshold_uncertainty_score":0.01388079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1144679112172922,"score_gpt":0.4008317522825131,"score_spread":0.2863638410652208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}