{"id":"W3049615191","doi":"10.1038/s41467-020-17898-8","title":"Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; McGill University Health Centre; Université de Montréal","funders":"National Institute on Drug Abuse; Canadian Institutes of Health Research; Government of Canada; McGill University; National Institute of Allergy and Infectious Diseases; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Delaney AIDS Research Enterprise; Styrelsen för Internationellt Utvecklingssamarbete; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; amfAR, The Foundation for AIDS Research","keywords":"Biology; T-cell receptor; Repertoire; Phenotype; Virology; Gene duplication; T cell; Immunology; Genetics; Immune system; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001145929,0.00007779562,0.0001277437,0.0002580232,0.0001658854,0.0002883754,0.0001036188,0.0001842133,0.0008304545],"category_scores_gemma":[0.0003552696,0.00008588436,0.0000917877,0.0001524476,0.0001176521,0.0001000195,0.000144235,0.000211984,0.0001416952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008556734,"about_ca_system_score_gemma":0.00005413732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004706084,"about_ca_topic_score_gemma":0.0007753588,"domain_scores_codex":[0.9999201,0.00001211637,0.000005841346,0.00001887637,0.00001890287,0.00002406681],"domain_scores_gemma":[0.9998368,0.00005054989,0.00003097092,0.00001886292,0.00003039922,0.00003242547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000391081,0.0000325473,0.05427923,0.00002136769,0.00001855487,0.000480429,0.0003447551,0.0002174996,0.9347455,0.00003526607,0.00006213221,0.009371554],"study_design_scores_gemma":[0.00002334427,0.0007874325,0.8053565,0.00001917258,0.0001120345,0.005999207,0.0005935424,0.003356504,0.1824394,0.0001304132,0.001166241,0.00001609831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993225,0.00008915774,0.0002322887,0.000006883779,0.000001090115,0.000002965116,0.00006801184,0.000006845795,0.0002701579],"genre_scores_gemma":[0.999353,0.00004679662,0.0002396897,0.00001429454,0.000002486996,0.000005088682,0.000115483,0.000003418613,0.000219808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008304545,"threshold_uncertainty_score":0.002778113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05320209384530911,"score_gpt":0.2815116670398223,"score_spread":0.2283095731945132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}