{"id":"W3049615691","doi":"10.3390/biomedicines8080290","title":"The Heat Shock Protein 27 Immune Complex Enhances Exosomal Cholesterol Efflux","year":2020,"lang":"en","type":"article","venue":"Biomedicines","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"","keywords":"Microvesicles; Hsp27; Exosome; Immune system; Heat shock protein; Cholesterol; Hsp70; Autoantibody; Secretion; Antibody; Chemistry; Cell biology; Immunology; Biology; Biochemistry; microRNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001829256,0.0002939936,0.0003330552,0.000192828,0.0001021066,0.0002516043,0.0001015568,0.0001873889,0.001909087],"category_scores_gemma":[0.0001966645,0.00008645224,0.0003337844,0.00009668527,0.0001659214,0.0001609037,0.0002835623,0.0003889494,0.0003939324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002074514,"about_ca_system_score_gemma":0.0001384009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003216824,"about_ca_topic_score_gemma":0.0003128982,"domain_scores_codex":[0.9998314,0.00004854208,0.00001288806,0.00002020343,0.00003569883,0.00005112876],"domain_scores_gemma":[0.9998658,0.00003214646,0.00001927904,0.00001830285,0.00002419006,0.00004026844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002472188,0.00003352208,0.000162739,0.00003952175,0.0000075528,0.00005295646,0.00000971035,0.00003008831,0.998288,0.0000559089,0.00006591832,0.001007006],"study_design_scores_gemma":[0.00001514722,0.0002920119,0.004324584,0.000005127833,0.00001160356,0.0001378232,0.00001982649,0.0004268559,0.9933548,0.00002316526,0.001385977,0.000003011618],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947522,0.001380707,0.002213472,0.0001243971,0.00004022359,0.00002389796,0.0002144365,0.000052906,0.001197804],"genre_scores_gemma":[0.9958394,0.0005453005,0.0008845954,0.00007546847,0.00001697734,0.00002025278,0.0003372764,0.00001919108,0.002261552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001909087,"threshold_uncertainty_score":0.006386518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01620876162612392,"score_gpt":0.2563910485012292,"score_spread":0.2401822868751053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}