{"id":"W3049624218","doi":"10.1084/jem.20200061","title":"A high-affinity antibody against the CSP N-terminal domain lacks <i>Plasmodium falciparum</i> inhibitory activity","year":2020,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Malaria Research and Control","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Research Council Canada; Canadian Institutes of Health Research; Canada Research Chairs; National Institutes of Health; Government of Saskatchewan; Western Economic Diversification Canada; Johns Hopkins Bloomberg School of Public Health; University of Saskatchewan; Hospital for Sick Children; Canada Foundation for Innovation; Natural Sciences and Engineering Research Council of Canada; Canadian Light Source; Canadian Institute for Advanced Research; Bill and Melinda Gates Foundation","keywords":"Circumsporozoite protein; Plasmodium falciparum; Epitope; Immunogen; Biology; Antibody; Virology; Monoclonal antibody; Glycan; Immunogenicity; Antigen; Malaria; Computational biology; Immunology; Glycoprotein; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001523523,0.0002614864,0.0006725514,0.00008141914,0.0002472556,0.00002095907,0.0004932242,0.00008300367,0.0003896031],"category_scores_gemma":[0.0003796726,0.0001193485,0.0001824832,0.0002591937,0.0006433885,0.0001552383,0.0001529486,0.001153495,0.00003025298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001183187,"about_ca_system_score_gemma":0.0002419098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007065858,"about_ca_topic_score_gemma":0.00000348346,"domain_scores_codex":[0.9971297,0.0005208049,0.0005680756,0.000170992,0.00119029,0.000420097],"domain_scores_gemma":[0.9981182,0.0004022255,0.0004094148,0.0003465879,0.0001607906,0.0005628103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008697513,0.0003500705,0.0001705589,0.00003353743,0.0002141716,0.000641861,0.003835682,0.000006074541,0.9693022,0.0001625327,0.01549938,0.001086419],"study_design_scores_gemma":[0.03554813,0.02121888,0.009839139,0.000984553,0.0007040757,0.00359013,0.01833728,0.0006583327,0.8910732,0.0002947451,0.01725593,0.0004955799],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8806923,0.002340247,0.000324503,0.1138954,0.0004102228,0.0004931458,0.00000566422,0.00001925258,0.001819279],"genre_scores_gemma":[0.9890536,0.000207238,0.0001017686,0.007525157,0.002957965,0.000007968553,0.000004635581,0.00002621105,0.0001154318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1083613,"threshold_uncertainty_score":0.5011426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0274002793002037,"score_gpt":0.3246438421017105,"score_spread":0.2972435628015068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}