{"id":"W3049624218","doi":"10.1084/jem.20200061","title":"A high-affinity antibody against the CSP N-terminal domain lacks <i>Plasmodium falciparum</i> inhibitory activity","year":2020,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Malaria Research and Control","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Research Council Canada; Canadian Institutes of Health Research; Canada Research Chairs; National Institutes of Health; Government of Saskatchewan; Western Economic Diversification Canada; Johns Hopkins Bloomberg School of Public Health; University of Saskatchewan; Hospital for Sick Children; Canada Foundation for Innovation; Natural Sciences and Engineering Research Council of Canada; Canadian Light Source; Canadian Institute for Advanced Research; Bill and Melinda Gates Foundation","keywords":"Circumsporozoite protein; Plasmodium falciparum; Epitope; Immunogen; Biology; Antibody; Virology; Monoclonal antibody; Glycan; Immunogenicity; Antigen; Malaria; Computational biology; Immunology; Glycoprotein; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001861675,0.000271816,0.0001907551,0.0001012719,0.00008026232,0.0001764575,0.0002604433,0.0003000423,0.001113718],"category_scores_gemma":[0.0001661742,0.00008240642,0.0001836928,0.00009371372,0.0001431586,0.0001572172,0.0001182369,0.000355016,0.0003137738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002859323,"about_ca_system_score_gemma":0.000184135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006951559,"about_ca_topic_score_gemma":0.0008373273,"domain_scores_codex":[0.9998752,0.00002211146,0.00001010555,0.00002446451,0.00003783952,0.00003024642],"domain_scores_gemma":[0.9999365,0.00001342396,0.00001262601,0.000006801058,0.00001273813,0.00001792175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004974481,0.00003464966,0.0003995848,0.00003752372,0.000008583479,0.00003738577,0.000004499092,0.0001184278,0.9972374,0.0001056792,0.00008409969,0.001882426],"study_design_scores_gemma":[0.00003409932,0.0008893276,0.005889364,0.000009097329,0.00003768966,0.0009757395,0.00001435561,0.002200292,0.9840319,0.00004163165,0.005869965,0.000006550586],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875542,0.001836493,0.007419794,0.0001538595,0.0000464516,0.00003216737,0.000240339,0.0000635505,0.002653124],"genre_scores_gemma":[0.9935283,0.000399555,0.004019584,0.0001704545,0.00001032705,0.000008340522,0.0006152884,0.000007376281,0.001240826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001113718,"threshold_uncertainty_score":0.003725767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0274002793002037,"score_gpt":0.3246438421017105,"score_spread":0.2972435628015068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}