{"id":"W3049630427","doi":"10.1038/s41589-020-0627-5","title":"Structural basis for diamide modulation of ryanodine receptor","year":2020,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":128,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"CIHR Skin Research Training Centre; National Key Research and Development Program of China; Canadian Institutes of Health Research; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Michael Smith Health Research BC; National Natural Science Foundation of China; Government of Canada; Japan Agency for Medical Research and Development","keywords":"Ryanodine receptor; RYR1; Mutagenesis; Biophysics; Binding site; Chemistry; Biology; Biochemistry; Receptor; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003594124,0.0001120758,0.0001629328,0.0000125947,0.00002038486,0.000002703834,0.0001524315,0.0005667771,0.00002541395],"category_scores_gemma":[0.0003860478,0.00009630778,0.0001028575,0.00006670123,0.00007843894,0.000001211716,0.00005009035,0.0001337809,0.000001580041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007403374,"about_ca_system_score_gemma":0.00002721497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001042444,"about_ca_topic_score_gemma":0.000001608653,"domain_scores_codex":[0.9993289,0.00001721844,0.0001713083,0.0002742873,0.00004412861,0.0001641445],"domain_scores_gemma":[0.9995894,0.00002510052,0.00007393181,0.0001349394,0.0001182165,0.00005844596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003126427,0.000006870841,0.000952079,0.00003141654,0.00002941423,6.828174e-8,0.00001652848,0.000008309587,0.9950738,0.000286645,0.001734227,0.001547978],"study_design_scores_gemma":[0.000354685,0.0002130799,0.0005051229,0.000003288571,0.00001067233,7.892209e-7,0.000006747607,0.0001313653,0.9763058,0.000278559,0.02207628,0.0001136307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968114,0.001036711,0.0006857651,0.0008761241,0.0001333314,0.0001495212,0.0001677396,0.00000880397,0.0001305391],"genre_scores_gemma":[0.9924976,0.00004866707,0.004993757,0.001012648,0.0005766516,0.00001097913,0.0008238203,0.00001227419,0.00002358463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02034205,"threshold_uncertainty_score":0.4371504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008771620724432733,"score_gpt":0.2600772219235729,"score_spread":0.2513056011991401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}