{"id":"W3049630427","doi":"10.1038/s41589-020-0627-5","title":"Structural basis for diamide modulation of ryanodine receptor","year":2020,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":128,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"CIHR Skin Research Training Centre; National Key Research and Development Program of China; Canadian Institutes of Health Research; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Michael Smith Health Research BC; National Natural Science Foundation of China; Government of Canada; Japan Agency for Medical Research and Development","keywords":"Ryanodine receptor; RYR1; Mutagenesis; Biophysics; Binding site; Chemistry; Biology; Biochemistry; Receptor; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001100264,0.0002386582,0.0002510264,0.00007754661,0.0003268026,0.0002405736,0.0005610746,0.0003930364,0.002877464],"category_scores_gemma":[0.0001635197,0.0001585701,0.0002281764,0.00004641514,0.0002841078,0.0002659715,0.0002452427,0.000795885,0.0009352473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000315643,"about_ca_system_score_gemma":0.0001896337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001950698,"about_ca_topic_score_gemma":0.0001950271,"domain_scores_codex":[0.9999312,0.000009805864,0.000006654484,0.00002182843,0.00001603713,0.00001432198],"domain_scores_gemma":[0.9999119,0.00001616568,0.00002221938,0.00001035828,0.00001123359,0.00002814765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000167395,0.00002340512,0.0001111691,0.00003502178,0.000006083244,0.0003516162,0.00001312906,0.0003585433,0.995359,0.002579997,0.0001401594,0.0008544017],"study_design_scores_gemma":[0.00008439864,0.0003599813,0.002403419,0.000007089433,0.00001538031,0.0009353074,0.00005260053,0.007528254,0.9821032,0.001916038,0.004577514,0.00001683738],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9731419,0.0008966254,0.01679483,0.001166077,0.0003612048,0.00005665626,0.0003088123,0.0003208853,0.006952864],"genre_scores_gemma":[0.9960207,0.0002670624,0.001802426,0.000183891,0.00003711422,0.0000156677,0.0002076368,0.00001725641,0.001448209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002877464,"threshold_uncertainty_score":0.009626091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008771620724432733,"score_gpt":0.2600772219235729,"score_spread":0.2513056011991401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}