{"id":"W3049639068","doi":"10.1111/mmi.14581","title":"Specialized and shared functions of diguanylate cyclases and phosphodiesterases in <i>Streptomyces</i> development","year":2020,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Deutsche Forschungsgemeinschaft","keywords":"Biology; Phosphodiesterase; Mutant; Streptomyces; Guanosine; Gene; Regulator; Transcriptome; Cell biology; Biochemistry; Genetics; Enzyme; Gene expression; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001012746,0.0004819117,0.0002732583,0.0004687745,0.000196604,0.0004548756,0.0001835588,0.0002312818,0.0007408445],"category_scores_gemma":[0.0001138251,0.0001702812,0.0002484723,0.0002811422,0.0001966422,0.0002159748,0.0004451389,0.0004131095,0.0003407739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004186975,"about_ca_system_score_gemma":0.0002545034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001467333,"about_ca_topic_score_gemma":0.001687154,"domain_scores_codex":[0.9998171,0.00001557079,0.00001284618,0.00007807588,0.00003206841,0.00004440885],"domain_scores_gemma":[0.9998598,0.00001250738,0.00004437438,0.00001790036,0.00001430871,0.00005117119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002619898,0.000004585071,0.0005779988,0.00001298944,0.000001704616,0.00002976218,0.000009034746,0.00002334737,0.9983121,0.0000503665,0.00001055569,0.0009414048],"study_design_scores_gemma":[0.00001786498,0.0002626419,0.2069481,0.00002290723,0.00003950623,0.001483857,0.0002407183,0.001985172,0.7808865,0.0003030535,0.00777865,0.00003113625],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939513,0.001085481,0.002206817,0.00005292268,0.00001425517,0.00001132891,0.0006578095,0.0001102979,0.00190995],"genre_scores_gemma":[0.9955297,0.0001975164,0.001602147,0.0000226345,0.000005410286,0.000007635897,0.001161045,0.00002014444,0.00145376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001467333,"threshold_uncertainty_score":0.00303787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01294927058888556,"score_gpt":0.2208468852365657,"score_spread":0.2078976146476801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}