{"id":"W3049639068","doi":"10.1111/mmi.14581","title":"Specialized and shared functions of diguanylate cyclases and phosphodiesterases in <i>Streptomyces</i> development","year":2020,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Deutsche Forschungsgemeinschaft","keywords":"Biology; Phosphodiesterase; Mutant; Streptomyces; Guanosine; Gene; Regulator; Transcriptome; Cell biology; Biochemistry; Genetics; Enzyme; Gene expression; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004710134,0.00012586,0.0003270769,0.00005733793,0.00002674603,0.000007417892,0.00003597598,0.00008377893,0.00010008],"category_scores_gemma":[0.0001027821,0.0001007695,0.0000305433,0.0001221434,0.0001241992,0.00002256768,0.00008317325,0.00009437267,0.000005004969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001241256,"about_ca_system_score_gemma":0.00003731769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002220417,"about_ca_topic_score_gemma":0.00001485818,"domain_scores_codex":[0.9992495,0.00003535853,0.0002468412,0.0002970347,0.000023398,0.0001478476],"domain_scores_gemma":[0.9997273,0.00002713279,0.00005978165,0.00008415651,0.00003591688,0.00006569963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002268363,0.00003986572,0.003334072,0.00009243024,0.000045114,0.00004461278,0.0002477063,3.31283e-7,0.9923274,0.000008484706,0.0005127945,0.003120374],"study_design_scores_gemma":[0.0009812163,0.0001330914,0.005646593,0.00006840195,0.00003861403,0.0000866588,0.00005058059,0.000001862034,0.9477479,0.000003882277,0.04512883,0.0001123559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942796,0.002801779,0.00001977595,0.002456573,0.00003843337,0.0002281626,0.00004059116,0.000013701,0.0001214131],"genre_scores_gemma":[0.9970253,0.0001413939,0.001220868,0.001433131,0.00002319945,0.000001302354,0.00007540134,0.000009455747,0.00006994309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04461604,"threshold_uncertainty_score":0.410926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01294927058888556,"score_gpt":0.2208468852365657,"score_spread":0.2078976146476801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}