{"id":"W3049662122","doi":"10.1186/s12986-020-00487-3","title":"Early leucine programming on protein utilization and mTOR signaling by DNA methylation in zebrafish (Danio rerio)","year":2020,"lang":"en","type":"article","venue":"Nutrition & Metabolism","topic":"Muscle metabolism and nutrition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"National Key Research and Development Program of China; Huazhong Agricultural University; National Natural Science Foundation of China","keywords":"Zebrafish; Biology; DNA methylation; PI3K/AKT/mTOR pathway; Epigenetics; Methylation; Leucine; Danio; Signal transduction; Cell biology; Amino acid; Biochemistry; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007757168,0.0003189392,0.0002037803,0.0003416334,0.0002215837,0.0001193754,0.0001830232,0.0002261168,0.001211467],"category_scores_gemma":[0.00008137774,0.0001843771,0.0002950195,0.0001080664,0.0002147421,0.0001545329,0.0002467642,0.0003324588,0.0001579615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004610643,"about_ca_system_score_gemma":0.0003779698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00662458,"about_ca_topic_score_gemma":0.01471549,"domain_scores_codex":[0.9999032,0.00000577959,0.000006665514,0.00003369047,0.00002605315,0.00002452942],"domain_scores_gemma":[0.9999382,0.000003932292,0.00002659752,0.000003253574,0.00001373103,0.0000142688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008467204,0.000004751421,0.0006617735,0.00002585687,0.00000332706,0.00002972378,0.00001998226,0.00002495164,0.9983848,0.00003487406,0.00003286429,0.0006924297],"study_design_scores_gemma":[0.00003737855,0.0005252669,0.1225447,0.00002470185,0.00008219647,0.0002471702,0.0001651994,0.001053397,0.8722078,0.000117777,0.002962794,0.0000316863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935441,0.001392219,0.002136112,0.0001115123,0.00003239477,0.0000259573,0.001084277,0.00008727791,0.001586194],"genre_scores_gemma":[0.9902401,0.0007750769,0.002505056,0.0001455983,0.000008317089,0.0001075521,0.0007685011,0.0000365125,0.005413326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00662458,"threshold_uncertainty_score":0.01317203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02287869693654436,"score_gpt":0.2490581232930842,"score_spread":0.2261794263565399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}