{"id":"W3049662122","doi":"10.1186/s12986-020-00487-3","title":"Early leucine programming on protein utilization and mTOR signaling by DNA methylation in zebrafish (Danio rerio)","year":2020,"lang":"en","type":"article","venue":"Nutrition & Metabolism","topic":"Muscle metabolism and nutrition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"National Key Research and Development Program of China; Huazhong Agricultural University; National Natural Science Foundation of China","keywords":"Zebrafish; Biology; DNA methylation; PI3K/AKT/mTOR pathway; Epigenetics; Methylation; Leucine; Danio; Signal transduction; Cell biology; Amino acid; Biochemistry; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002951563,0.0001958204,0.0002658455,0.0001343175,0.00005684201,0.00005924833,0.0001074095,0.0002014423,0.00001353638],"category_scores_gemma":[0.0001968192,0.0002153192,0.00005413384,0.0003674097,0.00003672646,0.00003386659,0.00004450786,0.0001615369,0.000003389904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001236404,"about_ca_system_score_gemma":0.00001774076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003924707,"about_ca_topic_score_gemma":0.00001417612,"domain_scores_codex":[0.9984623,0.0001995269,0.0003791653,0.0005073029,0.0002014454,0.0002502894],"domain_scores_gemma":[0.9995338,0.00001073678,0.0001127171,0.0001633362,0.00007026264,0.0001091769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000347335,0.0002345889,0.0002296075,0.0001037981,0.00000750894,0.000002490875,0.0001329099,0.000004745375,0.9811422,0.0002816982,0.0003487073,0.01716441],"study_design_scores_gemma":[0.005864218,0.0003276532,0.01650359,0.0001664258,0.00002402494,0.000001932016,0.000127197,0.0002022589,0.8535431,0.0004980494,0.1223737,0.0003678655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901044,0.00631169,0.001152615,0.001270076,0.00007168898,0.0009726061,0.00003631918,0.00002961597,0.00005096426],"genre_scores_gemma":[0.9957681,0.0007535277,0.001836049,0.0004338174,0.0004671099,0.0002317971,0.0004612326,0.00003169039,0.00001672114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1275991,"threshold_uncertainty_score":0.8780464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02287869693654436,"score_gpt":0.2490581232930842,"score_spread":0.2261794263565399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}