{"id":"W3049686259","doi":"10.1111/apt.15826","title":"A single nucleotide polymorphism genetic risk score to aid diagnosis of coeliac disease: a pilot study in clinical care","year":2020,"lang":"en","type":"article","venue":"Alimentary Pharmacology & Therapeutics","topic":"Celiac Disease Research and Management","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Human Genome Research Institute; Juvenile Diabetes Research Foundation International; University of Alberta; Diabetes UK; National Institutes of Health; Wellcome Trust","keywords":"Coeliac disease; Medicine; Single-nucleotide polymorphism; Human leukocyte antigen; Cohort; Receiver operating characteristic; Genotyping; Internal medicine; Immunology; Disease; Genotype; Genetics; Biology; Antigen; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002356953,0.0002580184,0.0005290956,0.0001744187,0.00006513096,0.0000114133,0.0002767458,0.00003416446,0.0005941854],"category_scores_gemma":[0.000004848693,0.0002492788,0.0001554091,0.0004246969,0.0001659257,0.00004766236,0.0003297521,0.0003433438,0.00007487879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001508076,"about_ca_system_score_gemma":0.0001867554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002797738,"about_ca_topic_score_gemma":0.00006983773,"domain_scores_codex":[0.997228,0.0005387022,0.0007042408,0.0005750374,0.0004583152,0.0004956524],"domain_scores_gemma":[0.9983217,0.0001958785,0.0001316811,0.000332413,0.0001019351,0.0009164306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008338538,0.009801163,0.9531732,0.0001563973,0.004848438,0.0008728695,0.001211244,0.00005377224,0.007611854,0.000001225912,0.002167738,0.01176355],"study_design_scores_gemma":[0.01450759,0.02550711,0.9227456,0.00007986762,0.01530388,0.000001713858,0.002101182,0.0002295172,0.004454605,0.00001396763,0.01472266,0.0003323101],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776718,0.007157693,0.00001129106,0.01130392,0.0003287625,0.003270339,0.0001570723,0.00005099803,0.00004811463],"genre_scores_gemma":[0.9584001,0.004035657,0.0001673658,0.03665024,0.0003276556,0.0003078541,0.00004581368,0.00004859919,0.00001672899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03042761,"threshold_uncertainty_score":0.9999959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1072668685426977,"score_gpt":0.3945888557560094,"score_spread":0.2873219872133117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}