{"id":"W3049702673","doi":"10.1016/j.ctrv.2020.102086","title":"Comparison of treatment-related adverse events of different Cyclin-dependent kinase 4/6 inhibitors in metastatic breast cancer: A network meta-analysis","year":2020,"lang":"en","type":"article","venue":"Cancer Treatment Reviews","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Palbociclib; Medicine; Fulvestrant; Tolerability; Metastatic breast cancer; Internal medicine; Oncology; Adverse effect; Neutropenia; Discontinuation; Breast cancer; Hazard ratio; Pharmacology; Cancer; Chemotherapy; Estrogen receptor; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001600175,0.0007456171,0.006243234,0.0002349993,0.00004555761,0.000003444625,0.0001687646,0.00009077136,0.00170309],"category_scores_gemma":[0.00001518822,0.0004596861,0.002652629,0.001521859,0.0001110025,0.0001092866,0.00004509998,0.0001582756,0.00001299726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001706954,"about_ca_system_score_gemma":0.0002749288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002328117,"about_ca_topic_score_gemma":0.001847163,"domain_scores_codex":[0.995777,0.0004195295,0.002153955,0.0007610099,0.0004032224,0.000485275],"domain_scores_gemma":[0.9972579,0.0001091586,0.001498679,0.0006739383,0.0001123966,0.0003479549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001839936,0.00350981,0.5756865,0.0009207398,0.206137,0.00005110854,0.003476573,0.0401513,0.001612142,0.00002540413,0.00005960133,0.1665299],"study_design_scores_gemma":[0.02328795,0.004351235,0.06173586,0.001160334,0.8769237,0.00001910753,0.0007676081,0.003155827,0.01324862,0.0001040396,0.0140893,0.001156425],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.4316022,0.5591402,0.000210654,0.00234144,0.0002420428,0.005309591,0.0009912589,0.00006739979,0.00009516309],"genre_scores_gemma":[0.957544,0.03928404,0.000516298,0.0001774946,0.0001043726,0.00195728,0.0001377866,0.00005629367,0.0002224932],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.6707867,"threshold_uncertainty_score":0.9997855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1381587461601385,"score_gpt":0.405004672436912,"score_spread":0.2668459262767735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}