{"id":"W3049717158","doi":"10.1021/acsomega.0c02419","title":"Synthesis of a <sup>11</sup>C-Isotopologue of the B-Raf-Selective Inhibitor Encorafenib Using In-Loop [<sup>11</sup>C]CO<sub>2</sub> Fixation","year":2020,"lang":"en","type":"article","venue":"ACS Omega","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Centre Hospitalier de l’Université de Montréal","funders":"Dana-Farber Cancer Institute","keywords":"Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000279289,0.0003135492,0.0004687725,0.0001152734,0.0001057875,0.00001810745,0.0004462072,0.000382277,0.000006492304],"category_scores_gemma":[0.0008652782,0.0002690504,0.0002256232,0.00051461,0.0002287344,0.00002127007,0.0002443057,0.0002043392,0.000007506301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004888851,"about_ca_system_score_gemma":0.000279769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001458912,"about_ca_topic_score_gemma":0.00009395049,"domain_scores_codex":[0.9978584,0.0002644723,0.0006039509,0.0005650278,0.000299922,0.0004082106],"domain_scores_gemma":[0.9986876,0.0001087988,0.0003680643,0.0005231718,0.000193123,0.0001191949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001499784,0.0001318243,0.01601591,0.000113478,0.00007015446,0.000006289526,0.0008025497,0.001967635,0.9788413,0.0001020941,0.0008445497,0.0009542067],"study_design_scores_gemma":[0.0006971477,0.0002674947,0.001762822,0.0000828601,0.00006953938,0.00001384659,0.0005769394,0.001904505,0.9930458,0.00007623964,0.00122883,0.0002739495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980781,0.0002282758,0.0002552205,0.00035402,0.00007582173,0.0005120346,0.0001371258,0.00001768003,0.0003417108],"genre_scores_gemma":[0.9989045,0.00005856612,0.0002404372,0.0002836142,0.0003150835,0.00005285323,0.00006702917,0.0000455003,0.0000323989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01425309,"threshold_uncertainty_score":0.9999762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01534743726039368,"score_gpt":0.2303034083146331,"score_spread":0.2149559710542394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}