{"id":"W3049717158","doi":"10.1021/acsomega.0c02419","title":"Synthesis of a <sup>11</sup>C-Isotopologue of the B-Raf-Selective Inhibitor Encorafenib Using In-Loop [<sup>11</sup>C]CO<sub>2</sub> Fixation","year":2020,"lang":"en","type":"article","venue":"ACS Omega","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Centre Hospitalier de l’Université de Montréal","funders":"Dana-Farber Cancer Institute","keywords":"Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001988909,0.0006509571,0.0003293891,0.0002442799,0.0002803788,0.0002072047,0.000479105,0.0004363323,0.003495964],"category_scores_gemma":[0.0001859195,0.000228238,0.0003104924,0.0004085415,0.0001737957,0.0003120991,0.0002816796,0.0005876071,0.002016119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004344267,"about_ca_system_score_gemma":0.0005695142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001472894,"about_ca_topic_score_gemma":0.00197034,"domain_scores_codex":[0.9998606,0.00001668161,0.00001095432,0.00003391333,0.00003641149,0.00004139998],"domain_scores_gemma":[0.9998757,0.00001797735,0.0000242277,0.00001878151,0.00002986428,0.00003348295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002368975,0.00007336074,0.00009515484,0.0001215503,0.00001667465,0.0002097174,0.00004519413,0.0006924231,0.9909357,0.0004999151,0.000247895,0.006825546],"study_design_scores_gemma":[0.00003223627,0.0002922176,0.0003854223,0.000005034504,0.00001696085,0.0001737629,0.00001120276,0.0005396089,0.9900633,0.00004423801,0.008422722,0.00001324428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9014454,0.002988866,0.07093687,0.000245084,0.0001759127,0.001002495,0.003173579,0.0006760221,0.01935575],"genre_scores_gemma":[0.9378877,0.002410221,0.03914859,0.0001485773,0.00003575215,0.0003850294,0.003619439,0.0003105994,0.01605409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003495964,"threshold_uncertainty_score":0.01169515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01534743726039368,"score_gpt":0.2303034083146331,"score_spread":0.2149559710542394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}