{"id":"W3052464567","doi":"10.1038/s41431-020-00709-5","title":"Cancer surveillance for individuals with Li-Fraumeni syndrome","year":2020,"lang":"en","type":"letter","venue":"European Journal of Human Genetics","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Li–Fraumeni syndrome; Cancer; Genetics; Biology; Medicine; Computational biology; Mutation; Gene; Germline mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007015012,0.0002642492,0.0005717528,0.0006956622,0.001985847,0.0009816815,0.0006761386,0.01336095,0.003450591],"category_scores_gemma":[0.007666165,0.0002516715,0.0005383703,0.0005075983,0.0007661339,0.0009250508,0.0006671298,0.006665246,0.001122619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0017284,"about_ca_system_score_gemma":0.001869328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008416571,"about_ca_topic_score_gemma":0.009761906,"domain_scores_codex":[0.9993361,0.0002038081,0.0000967656,0.00008809593,0.0001019433,0.0001732666],"domain_scores_gemma":[0.9971948,0.001209723,0.0002598351,0.00008743977,0.0003885334,0.0008597022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003174265,0.0002009971,0.1262676,0.0002412292,0.00007929603,0.1294611,0.001048989,0.0005416948,0.002909663,0.003123124,0.6714646,0.06434437],"study_design_scores_gemma":[0.0005370522,0.0009496569,0.1016333,0.002432956,0.0004861102,0.3554379,0.005532556,0.006772141,0.002621696,0.02306659,0.5003361,0.0001940446],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.02591094,0.004478753,0.0002831842,0.9507817,0.007959266,0.00003295161,0.0002343165,0.00005846991,0.01026045],"genre_scores_gemma":[0.3236589,0.006314157,0.001875266,0.6112303,0.04523895,0.0001077956,0.0003452434,0.00005999232,0.01116953],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01336095,"threshold_uncertainty_score":0.01673514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02838184845818962,"score_gpt":0.2658151877327385,"score_spread":0.2374333392745489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}