{"id":"W3052464567","doi":"10.1038/s41431-020-00709-5","title":"Cancer surveillance for individuals with Li-Fraumeni syndrome","year":2020,"lang":"en","type":"letter","venue":"European Journal of Human Genetics","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Li–Fraumeni syndrome; Cancer; Genetics; Biology; Medicine; Computational biology; Mutation; Gene; Germline mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0004557822,0.0004891095,0.001031519,0.0002776108,0.0001140782,0.00008077966,0.0005402809,0.0001758646,0.0001612643],"category_scores_gemma":[0.00006007286,0.0004063834,0.0003871129,0.0001942998,0.0001539092,0.00003041449,0.00009448804,0.00240172,0.00003227306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001794963,"about_ca_system_score_gemma":0.0004720268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000154396,"about_ca_topic_score_gemma":0.000003297917,"domain_scores_codex":[0.996905,0.0003383305,0.0009863125,0.0004207985,0.000875544,0.0004739766],"domain_scores_gemma":[0.9973099,0.00006262915,0.001328869,0.0005092528,0.0005285314,0.0002608218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001155113,0.00003616235,0.0008719506,0.0004862774,0.001263003,0.01942915,0.000298403,0.0001312724,0.001473802,0.000001012747,0.9745967,0.001296727],"study_design_scores_gemma":[0.003938828,0.005765639,0.002904335,0.001245682,0.0008921603,0.003876091,0.00001640572,0.000008615735,0.0005350125,0.0000166481,0.9803258,0.0004748456],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.1451635,0.03787028,0.006066545,0.7964026,0.003762726,0.003485895,0.001252976,0.0002031671,0.005792278],"genre_scores_gemma":[0.1374276,0.00284239,0.01785693,0.8056992,0.02814573,0.00003519066,0.0006642502,0.001805876,0.00552281],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03502789,"threshold_uncertainty_score":0.9998998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02838184845818962,"score_gpt":0.2658151877327385,"score_spread":0.2374333392745489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}