{"id":"W3053707155","doi":"10.1158/1538-7445.am2020-6408","title":"Abstract 6408: E3<i>scan</i>™ ligand binding assay platform for targeted protein degradation and PROTAC discovery","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Tellabs (Canada)","funders":"","keywords":"Drug discovery; Ubiquitin ligase; Computational biology; Protein degradation; Cereblon; Mdm2; Neddylation; Ubiquitin; Biology; Bioinformatics; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002011311,0.001104309,0.000560321,0.001350992,0.0004320644,0.001215163,0.001099093,0.001103606,0.01603383],"category_scores_gemma":[0.0008421896,0.0004751106,0.0005054277,0.0008296275,0.00051213,0.0007443992,0.000849658,0.001316067,0.01234434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008209586,"about_ca_system_score_gemma":0.000688633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009029356,"about_ca_topic_score_gemma":0.001318782,"domain_scores_codex":[0.9988637,0.0001542372,0.00007742594,0.0001920427,0.0006089638,0.0001036619],"domain_scores_gemma":[0.9994229,0.0001153331,0.00009868836,0.0001105822,0.0001693302,0.00008322694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004095146,0.0001342228,0.0007889409,0.0002248454,0.00004314692,0.0002294207,0.00005090486,0.0005111825,0.9548751,0.003003328,0.01409636,0.02563299],"study_design_scores_gemma":[0.00003348709,0.0001624872,0.0008939165,0.00001690146,0.00001575098,0.0004516689,0.00001225787,0.002237683,0.9500401,0.0003130075,0.04579123,0.00003144528],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2526829,0.006758974,0.5656095,0.002103275,0.0008490311,0.001462968,0.02617571,0.05555522,0.08880246],"genre_scores_gemma":[0.4684657,0.004712404,0.3751859,0.00151954,0.000153831,0.002132809,0.03712519,0.004141183,0.1065634],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01603383,"threshold_uncertainty_score":0.05363852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0657233218218696,"score_gpt":0.3512274735468794,"score_spread":0.2855041517250099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}