{"id":"W3055748198","doi":"10.1093/nar/gkaa664","title":"Location specific annealing of miR-122 and other small RNAs defines an Hepatitis C Virus 5′ UTR regulatory element with distinct impacts on virus translation and genome stability","year":2020,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Hepatitis C virus research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Saskatchewan","keywords":"Internal ribosome entry site; Biology; RNA; Small RNA; Untranslated region; Virology; RNA-dependent RNA polymerase; Viral replication; Five prime untranslated region; NS2-3 protease; Non-coding RNA; Hepatitis C virus; Virus; Genetics; Gene; Ribosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001757514,0.0002476476,0.000288404,0.0002897158,0.0001976251,0.0003145888,0.000113347,0.0002819246,0.0008639638],"category_scores_gemma":[0.000380207,0.0002687782,0.0003744901,0.0001266298,0.0002690096,0.0001689837,0.0001898618,0.0003355096,0.0004166086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003060335,"about_ca_system_score_gemma":0.0002457089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006019725,"about_ca_topic_score_gemma":0.001034224,"domain_scores_codex":[0.9997663,0.00004818232,0.00001580891,0.00007152853,0.000062889,0.00003516773],"domain_scores_gemma":[0.999779,0.00006560274,0.00007019191,0.00002181939,0.00003000258,0.00003331632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008526309,0.0000106064,0.000593111,0.00001413907,0.000002685634,0.00002428851,0.00001664905,0.0001159942,0.9975999,0.0001421091,0.00001017651,0.001384984],"study_design_scores_gemma":[0.00001128026,0.0004180339,0.02956147,0.000008020374,0.00002446843,0.0003792721,0.00003292093,0.002769116,0.9646427,0.0001641169,0.001975543,0.00001296237],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912527,0.0008294833,0.006324483,0.00003008866,0.00001312106,0.00002407386,0.0001011102,0.00006485077,0.001360056],"genre_scores_gemma":[0.9920315,0.0002232002,0.006511645,0.00003531156,0.000007843038,0.00002103565,0.0002390505,0.00002050779,0.0009100648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008639638,"threshold_uncertainty_score":0.002890289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1559693365278634,"score_gpt":0.3514272265409906,"score_spread":0.1954578900131272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}