{"id":"W3055805238","doi":"10.1111/mec.15602","title":"Large‐scale prion protein genotyping in Canadian caribou populations and potential impact on chronic wasting disease susceptibility","year":2020,"lang":"en","type":"article","venue":"Molecular Ecology","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; Canadian Food Inspection Agency; University of Saskatchewan; University of Calgary","funders":"Genome Alberta; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Alberta Agriculture and Forestry; Genome Canada","keywords":"Chronic wasting disease; Biology; PRNP; Single-nucleotide polymorphism; Genotyping; Genotype; Subspecies; Genetics; Allele; Zoology; Gene; Disease; Scrapie; Prion protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006539053,0.0003338738,0.0002945544,0.001288214,0.001691408,0.0006913386,0.0006185746,0.0002990718,0.0007452345],"category_scores_gemma":[0.001726759,0.0001854366,0.0002452691,0.001813672,0.0007592067,0.0001673271,0.0004238522,0.0002719538,0.00007631912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00314247,"about_ca_system_score_gemma":0.003285173,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9091999,"about_ca_topic_score_gemma":0.9592031,"domain_scores_codex":[0.9994456,0.00006794799,0.00002813084,0.0001750368,0.0001373885,0.0001459517],"domain_scores_gemma":[0.9991781,0.0001225029,0.0001175856,0.00006728878,0.0003467908,0.0001677625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000187934,0.00002612039,0.9790838,0.00001846913,0.00007855103,0.0002870861,0.002012873,0.0001447512,0.01257298,0.00009708494,0.0001288466,0.005361514],"study_design_scores_gemma":[0.000003732459,0.00002540385,0.9984024,0.000006049632,0.00002482424,0.0001194501,0.0006820359,0.0001241761,0.0002672617,0.0000179695,0.0003206385,0.000006114047],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993634,0.00007806896,0.0001077479,0.00001350191,0.000001609357,0.000005998798,0.000154894,0.000002148245,0.000272547],"genre_scores_gemma":[0.9988901,0.0001079008,0.0003089903,0.00001915518,0.000001268384,0.000007199453,0.0002880626,0.000003639351,0.0003736404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09080011,"threshold_uncertainty_score":0.1826696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008385026290802509,"score_gpt":0.2573533176721436,"score_spread":0.2489682913813411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}