{"id":"W305719300","doi":"10.1182/blood.v124.21.4269.4269","title":"A Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial Demonstrating Reversal of Edoxaban-Induced Anticoagulation in Healthy Subjects By Andexanet Alfa (PRT064445), a Universal Antidote for Factor Xa (fXa) Inhibitors","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Atrial Fibrillation Management and Outcomes","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; McMaster University; St. Joseph's Hospital","funders":"","keywords":"Medicine; Edoxaban; Rivaroxaban; Apixaban; Pharmacodynamics; Placebo; Warfarin; Pharmacology; Dabigatran; Anticoagulant; Pharmacokinetics; Antidote; Anesthesia; Internal medicine; Atrial fibrillation; Toxicity; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003575001,0.002228528,0.003390594,0.00047764,0.0006243607,0.001592879,0.001030408,0.002894284,0.008874768],"category_scores_gemma":[0.003326692,0.0008624286,0.002009965,0.0003676165,0.001512998,0.001646573,0.0004604075,0.003509522,0.001446492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005631585,"about_ca_system_score_gemma":0.001505009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004593127,"about_ca_topic_score_gemma":0.0008932226,"domain_scores_codex":[0.9986443,0.0006934483,0.0001029523,0.0002944969,0.00009202485,0.0001727106],"domain_scores_gemma":[0.9982312,0.0004958703,0.0004064539,0.0001794114,0.0001941316,0.0004929174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9803265,0.008972611,0.0002163845,0.0004717319,0.0005975742,0.0000324339,0.00003425402,0.00007555281,0.002925683,0.00006429579,0.0005193058,0.005763773],"study_design_scores_gemma":[0.9611411,0.0375878,0.0004822926,0.00001259828,0.0001795295,0.00001496232,0.000005974485,0.00009639389,0.0001901749,0.00004695744,0.0002357316,0.000006422935],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9717662,0.00569211,0.001772579,0.001418609,0.001845213,0.01213615,0.001833315,0.0003055688,0.003230465],"genre_scores_gemma":[0.9662464,0.003930002,0.004483343,0.003088141,0.001545093,0.01285376,0.002105561,0.00006249028,0.005685195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008874768,"threshold_uncertainty_score":0.02968907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05092395364783939,"score_gpt":0.3414302909452548,"score_spread":0.2905063372974154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}