{"id":"W305719300","doi":"10.1182/blood.v124.21.4269.4269","title":"A Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial Demonstrating Reversal of Edoxaban-Induced Anticoagulation in Healthy Subjects By Andexanet Alfa (PRT064445), a Universal Antidote for Factor Xa (fXa) Inhibitors","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Atrial Fibrillation Management and Outcomes","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; McMaster University; St. Joseph's Hospital","funders":"","keywords":"Medicine; Edoxaban; Rivaroxaban; Apixaban; Pharmacodynamics; Placebo; Warfarin; Pharmacology; Dabigatran; Anticoagulant; Pharmacokinetics; Antidote; Anesthesia; Internal medicine; Atrial fibrillation; Toxicity; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001445882,0.0002814136,0.001600237,0.0003960294,0.00009736585,0.00003371574,0.00008339425,0.0002132438,0.00002894282],"category_scores_gemma":[0.0008915457,0.0002429107,0.0004029427,0.0003211375,0.00006311781,0.0002110325,0.00002742568,0.0001618288,0.000002859392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004302506,"about_ca_system_score_gemma":0.0001654429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001178304,"about_ca_topic_score_gemma":0.00004191165,"domain_scores_codex":[0.9974293,0.0003179234,0.001103787,0.0003845384,0.0004025966,0.0003618853],"domain_scores_gemma":[0.9976929,0.001133419,0.0006943253,0.0002238961,0.0001164946,0.0001389995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9770768,0.0003873967,0.003911341,0.0001370609,0.0003413373,0.000002853149,0.0001971332,0.00001467024,0.01693078,0.0002355017,0.0000829843,0.0006821024],"study_design_scores_gemma":[0.9822971,0.002625612,0.00006021897,0.00009388552,0.0008816076,0.000002679304,0.0001073422,0.004325957,0.009202361,0.00003555715,0.0001497869,0.0002178824],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985889,0.00008079461,0.001363759,0.0007074669,0.0004599495,0.01095854,0.00002022894,0.00006612128,0.0004541172],"genre_scores_gemma":[0.9977909,0.00002224519,0.0007832302,0.00005901715,0.0009333036,0.00005251344,0.0001743648,0.00003294393,0.000151537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01190182,"threshold_uncertainty_score":0.9905612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05092395364783939,"score_gpt":0.3414302909452548,"score_spread":0.2905063372974154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}