{"id":"W3057476791","doi":"10.3390/ph13090201","title":"In Vitro Modeling of Bradykinin-Mediated Angioedema States","year":2020,"lang":"en","type":"review","venue":"Pharmaceuticals","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; Université Laval","funders":"Canadian Institutes of Health Research; Shire; Novo Nordisk; Baxalta; CSL Behring; Biogen; Pfizer","keywords":"Bradykinin; Angioedema; In vitro; Medicine; Hereditary angioedema; Pharmacology; Computational biology; Chemistry; Biology; Internal medicine; Immunology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001645506,0.000498915,0.0003013866,0.0002185773,0.0001741206,0.000644997,0.0004164185,0.000390141,0.001065908],"category_scores_gemma":[0.0001781664,0.0001626981,0.000224579,0.0002045055,0.0001702819,0.0002762277,0.0002275611,0.0005257858,0.0006117258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003421111,"about_ca_system_score_gemma":0.0001510524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008120462,"about_ca_topic_score_gemma":0.0007091735,"domain_scores_codex":[0.9998556,0.00003293993,0.00000976211,0.00002222196,0.00005534875,0.00002413087],"domain_scores_gemma":[0.9999042,0.00003389204,0.00002027507,0.000008745383,0.00001776137,0.00001518935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002406193,0.0002022699,0.0007052553,0.0004248144,0.00004181136,0.0004040903,0.00007947518,0.07308869,0.910564,0.006087362,0.001142112,0.007019533],"study_design_scores_gemma":[0.0000634215,0.0009354806,0.001836504,0.00005440733,0.00007004598,0.0006132358,0.00008161993,0.3592433,0.6030539,0.002986328,0.03102142,0.00004047136],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.7494633,0.02815036,0.1676829,0.001049797,0.0006440639,0.0004544032,0.003544463,0.000782257,0.04822842],"genre_scores_gemma":[0.9567862,0.01484278,0.01907491,0.0001178679,0.00006879742,0.0002456163,0.001686866,0.000056176,0.007120735],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001065908,"threshold_uncertainty_score":0.003565848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1267336698798003,"score_gpt":0.424261970194427,"score_spread":0.2975283003146267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}