{"id":"W3057625252","doi":"10.1016/j.celrep.2020.108037","title":"Affinity for the Interface Underpins Potency of Antibodies Operating In Membrane Environments","year":2020,"lang":"en","type":"article","venue":"Cell Reports","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Biotechnology and Biological Sciences Research Council; National Institute of Allergy and Infectious Diseases; Medical Research Council; European Commission; Euskal Herriko Unibertsitatea; Canada Research Chairs; Eusko Jaurlaritza; Deutsche Forschungsgemeinschaft; Wolfson Foundation; Japan Agency for Medical Research and Development; Japan Society for the Promotion of Science; James B. Pendleton Charitable Trust; Ministerio de Ciencia e Innovación; Wellcome Trust","keywords":"Epitope; Membrane; Antibody; Chemistry; Glycoprotein; Molecular recognition; Biophysics; Antigen; Membrane protein; Human immunodeficiency virus (HIV); Cell membrane; Lipid bilayer; Cell biology; Virology; Biochemistry; Biology; Molecule; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002833231,0.0003302031,0.0002679228,0.0001452819,0.0001906419,0.0005034481,0.0002748066,0.0004047852,0.001572665],"category_scores_gemma":[0.0006694318,0.0001623299,0.0001688642,0.0001069837,0.0003238253,0.0003979425,0.0003973065,0.0004378886,0.0005007188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003455265,"about_ca_system_score_gemma":0.000188162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005137194,"about_ca_topic_score_gemma":0.0004774077,"domain_scores_codex":[0.9997067,0.00005038579,0.00001390286,0.00004927022,0.00008843927,0.00009130722],"domain_scores_gemma":[0.9997079,0.0001371351,0.00005880028,0.00001864858,0.00004346814,0.00003410006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008896145,0.00003100378,0.001142995,0.00007077024,0.00001196273,0.00005363269,0.00002165085,0.002092573,0.9921928,0.0007689507,0.00003944524,0.003485366],"study_design_scores_gemma":[0.00000750128,0.0003358011,0.003387158,0.000008695217,0.00002231708,0.0001585923,0.00003829845,0.008624075,0.9859445,0.0004488378,0.00101267,0.00001156603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989032,0.001067787,0.00691717,0.00008519062,0.00001377985,0.0000205439,0.00004548667,0.00003915595,0.002778975],"genre_scores_gemma":[0.9987223,0.0002490946,0.0007059252,0.00001856302,0.000002661938,0.000007149626,0.0000243949,0.000004379967,0.0002655878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001572665,"threshold_uncertainty_score":0.005261123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02744084683178787,"score_gpt":0.2797223918836328,"score_spread":0.2522815450518449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}