{"id":"W3057625252","doi":"10.1016/j.celrep.2020.108037","title":"Affinity for the Interface Underpins Potency of Antibodies Operating In Membrane Environments","year":2020,"lang":"en","type":"article","venue":"Cell Reports","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Biotechnology and Biological Sciences Research Council; National Institute of Allergy and Infectious Diseases; Medical Research Council; European Commission; Euskal Herriko Unibertsitatea; Canada Research Chairs; Eusko Jaurlaritza; Deutsche Forschungsgemeinschaft; Wolfson Foundation; Japan Agency for Medical Research and Development; Japan Society for the Promotion of Science; James B. Pendleton Charitable Trust; Ministerio de Ciencia e Innovación; Wellcome Trust","keywords":"Epitope; Membrane; Antibody; Chemistry; Glycoprotein; Molecular recognition; Biophysics; Antigen; Membrane protein; Human immunodeficiency virus (HIV); Cell membrane; Lipid bilayer; Cell biology; Virology; Biochemistry; Biology; Molecule; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001519686,0.00007627661,0.0001494356,0.00001710189,0.00007999925,0.00000494395,0.00007506796,0.00005274195,0.0001695877],"category_scores_gemma":[0.0001297583,0.00004993026,0.00004862798,0.00004026921,0.00009365008,0.00002745525,0.00007110644,0.0001079735,0.0000475083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001671982,"about_ca_system_score_gemma":0.00003888709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000900084,"about_ca_topic_score_gemma":0.00001902254,"domain_scores_codex":[0.9993349,0.00005112899,0.0002396833,0.0001723382,0.00002672537,0.0001752819],"domain_scores_gemma":[0.9995947,0.0001340106,0.00008626848,0.0001586514,0.000009677775,0.00001664676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003637887,0.000176298,0.01487279,0.00004709444,0.00008336168,0.00006865162,0.00115392,0.0001846791,0.9814565,0.000007325446,0.0005806034,0.001332421],"study_design_scores_gemma":[0.0006012875,0.0002205447,0.008615557,0.00001498419,0.00001888514,0.00002382635,0.0005937829,0.00001655787,0.978111,0.00002101513,0.01169954,0.00006302151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924048,0.003461289,0.0005764778,0.0006497322,0.0001189808,0.000500834,0.00002193227,0.000009480044,0.002256457],"genre_scores_gemma":[0.9983273,0.0002188847,0.0000882421,0.00003937469,0.000006746355,0.000022798,0.0000399987,0.000006265021,0.001250447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01111894,"threshold_uncertainty_score":0.2036097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02744084683178787,"score_gpt":0.2797223918836328,"score_spread":0.2522815450518449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}