{"id":"W3061112347","doi":"10.1016/j.str.2020.07.016","title":"Nucleotide Binding, Evolutionary Insights, and Interaction Partners of the Pseudokinase Unc-51-like Kinase 4","year":2020,"lang":"en","type":"article","venue":"Structure","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital; Princess Margaret Cancer Centre; University Health Network","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; National Institutes of Health; Shenzhen Gas Corporation; Innovative Medicines Initiative; Novartis Pharma; Deutschen Konsortium für Translationale Krebsforschung; Canada Foundation for Innovation; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Genome Canada; Boehringer Ingelheim; Takeda Pharmaceutical Company; Janssen Pharmaceuticals; Merck KGaA; Meso Scale Diagnostics; Pfizer","keywords":"Kinase; Biology; Cell biology; Binding site; Plasma protein binding; Genetics; Sequence alignment; Biochemistry; Peptide sequence; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00001104191,0.0001165659,0.00009337013,0.00001462731,0.00007614653,0.00001197697,0.000114836,0.00008032628,0.00003954784],"category_scores_gemma":[0.00006851409,0.00008026426,0.00006779395,0.00007807969,0.0001256206,0.000005535988,0.0001216619,0.00009727978,0.000001203848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007034383,"about_ca_system_score_gemma":0.00004506326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001177019,"about_ca_topic_score_gemma":0.00001088362,"domain_scores_codex":[0.9993901,0.00004125073,0.0001264115,0.0002320094,0.0001033634,0.0001068282],"domain_scores_gemma":[0.9995739,0.000006251426,0.00008553077,0.0001920471,0.00003728248,0.0001049274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002490318,0.00002673649,0.02680734,0.00009431669,0.00007132173,0.00001081287,0.0002974871,0.0002942905,0.9532677,0.001053735,0.01695225,0.0008749762],"study_design_scores_gemma":[0.002418063,0.0004926652,0.0734342,0.0001094091,0.0001932556,0.00006016102,0.001571969,0.0009879635,0.793387,0.001334797,0.1253398,0.0006707094],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980713,0.0006736692,0.00002140494,0.0003971856,0.0001891004,0.0001092908,0.0001016931,0.000007386747,0.0004290315],"genre_scores_gemma":[0.9990372,0.00007038097,0.0001256371,0.0004837259,0.0001247058,0.000002950835,0.00007973201,0.00001113738,0.00006452131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1598807,"threshold_uncertainty_score":0.3273081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007424343181959917,"score_gpt":0.2389751694104225,"score_spread":0.2315508262284625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}