{"id":"W3061112347","doi":"10.1016/j.str.2020.07.016","title":"Nucleotide Binding, Evolutionary Insights, and Interaction Partners of the Pseudokinase Unc-51-like Kinase 4","year":2020,"lang":"en","type":"article","venue":"Structure","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital; Princess Margaret Cancer Centre; University Health Network","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; National Institutes of Health; Shenzhen Gas Corporation; Innovative Medicines Initiative; Novartis Pharma; Deutschen Konsortium für Translationale Krebsforschung; Canada Foundation for Innovation; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Genome Canada; Boehringer Ingelheim; Takeda Pharmaceutical Company; Janssen Pharmaceuticals; Merck KGaA; Meso Scale Diagnostics; Pfizer","keywords":"Kinase; Biology; Cell biology; Binding site; Plasma protein binding; Genetics; Sequence alignment; Biochemistry; Peptide sequence; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001574207,0.0002587911,0.0003302047,0.0004654712,0.0005181108,0.0006241981,0.0004413137,0.0004835572,0.001140031],"category_scores_gemma":[0.0002350181,0.0001892312,0.0001904148,0.0003422375,0.0003414835,0.0004820881,0.0003472458,0.000560423,0.0006336805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000617328,"about_ca_system_score_gemma":0.00026579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001349936,"about_ca_topic_score_gemma":0.001634,"domain_scores_codex":[0.9998955,0.00002440926,0.000007195971,0.00002155984,0.00002877101,0.00002265776],"domain_scores_gemma":[0.999869,0.0000267191,0.0000409255,0.00001752484,0.00001670397,0.00002913293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006647776,0.00007363609,0.004376747,0.00009971869,0.0000237616,0.001012511,0.0001356257,0.003521607,0.9725047,0.00699093,0.0002411875,0.01035484],"study_design_scores_gemma":[0.00007525519,0.0004164449,0.130172,0.00007403662,0.0001620047,0.00814088,0.0009348054,0.05161301,0.7376572,0.007202814,0.06343459,0.0001171097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880859,0.003278786,0.003501767,0.0002294217,0.00002631805,0.000006385005,0.00009984046,0.00004104085,0.004730601],"genre_scores_gemma":[0.9943024,0.000859773,0.002138435,0.00005968439,0.000008373322,0.000003260182,0.0002448682,0.00001199565,0.002371249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001349936,"threshold_uncertainty_score":0.004479051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007424343181959917,"score_gpt":0.2389751694104225,"score_spread":0.2315508262284625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}