{"id":"W3061354765","doi":"10.1126/science.aay5356","title":"Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy","year":2020,"lang":"en","type":"article","venue":"Science","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":288,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Centre Hospitalier Universitaire Sainte-Justine; Montreal Clinical Research Institute; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Agence Nationale de la Recherche; Canadian Diabetes Association; Canadian Institutes of Health Research; Mitacs; Heart and Stroke Foundation of Canada; Burroughs Wellcome Fund","keywords":"Diabetic retinopathy; Clearance; Neutrophil extracellular traps; Retinopathy; Blindness; Inflammation; Retinal; Extracellular; Medicine; Pathological; Pathology; Biology; Cell biology; Immunology; Diabetes mellitus; Ophthalmology; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003210494,0.0003121542,0.0002314764,0.0002178923,0.0001633549,0.0003454316,0.0001646115,0.0003410389,0.001157685],"category_scores_gemma":[0.0001066674,0.0001345871,0.0001922321,0.00007617603,0.0002540605,0.0003076298,0.0003076032,0.0008355695,0.0002000011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001515434,"about_ca_system_score_gemma":0.0002114918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001757338,"about_ca_topic_score_gemma":0.0005760298,"domain_scores_codex":[0.9998868,0.00003577405,0.000007239563,0.00001659579,0.00002097464,0.00003259265],"domain_scores_gemma":[0.9999183,0.00001239377,0.00002753425,0.000008151739,0.000009886255,0.00002364667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002059343,0.00006230381,0.0002397475,0.00009211234,0.000007591598,0.0001013828,0.00002548977,0.0000628501,0.9932944,0.0006058224,0.000114663,0.005187688],"study_design_scores_gemma":[0.0001228567,0.002244814,0.007574009,0.00006902839,0.00004593417,0.001239614,0.0001132063,0.001357916,0.9762884,0.0009153829,0.01001429,0.00001445465],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9507252,0.02935607,0.01582125,0.0009389743,0.0001860215,0.0001253433,0.0001946925,0.0001467635,0.002505652],"genre_scores_gemma":[0.9864,0.006821195,0.004435748,0.0002617722,0.00003848251,0.00004355694,0.00008170167,0.00001113203,0.001906316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001157685,"threshold_uncertainty_score":0.003872812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02468125903191598,"score_gpt":0.253013923406219,"score_spread":0.2283326643743031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}