{"id":"W3061843793","doi":"10.1056/nejmoa2004215","title":"Evinacumab for Homozygous Familial Hypercholesterolemia","year":2020,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":764,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Chicoutimi","funders":"Massachusetts Medical Society; Regeneron Pharmaceuticals","keywords":"Familial hypercholesterolemia; Internal medicine; Null allele; Null (SQL); Endocrinology; LDL receptor; Medicine; PCSK9; Cholesterol; Lipoprotein; Ldl cholesterol; Gene; Biology; Genetics; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000453422,0.0001584323,0.00068058,0.0001056956,0.00003735725,0.000007124139,0.0001381892,0.0000715465,0.0002019624],"category_scores_gemma":[0.001370047,0.00009862772,0.0001445662,0.0001520145,0.0000803633,0.00009649665,0.00001613504,0.0003009133,0.00001139269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001993761,"about_ca_system_score_gemma":0.0002761584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002268849,"about_ca_topic_score_gemma":0.000003448681,"domain_scores_codex":[0.9986226,0.00004033416,0.0005477523,0.0001407962,0.0004329551,0.000215561],"domain_scores_gemma":[0.9985655,0.0001609762,0.0002139823,0.0001302583,0.0002381786,0.0006911256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.009531002,0.0001325817,0.004082104,0.0003158329,0.0002337967,0.000380252,0.005561932,0.00002575343,0.02343947,0.0003868917,0.2705256,0.6853848],"study_design_scores_gemma":[0.1275256,0.004653147,0.003579984,0.0002421549,0.0006614242,0.001508371,0.0006410757,0.00008070513,0.0004420481,0.0003559876,0.8601929,0.0001166692],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8123875,0.008185246,0.01151511,0.1610302,0.00224414,0.000559186,0.00001017621,0.00004420728,0.00402424],"genre_scores_gemma":[0.9597967,0.0006576029,0.002424821,0.01267395,0.0237771,0.000002054156,0.00001060848,0.00003107724,0.0006261368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6852681,"threshold_uncertainty_score":0.4021922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04030542860642669,"score_gpt":0.2954700934863164,"score_spread":0.2551646648798896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}