{"id":"W3061843793","doi":"10.1056/nejmoa2004215","title":"Evinacumab for Homozygous Familial Hypercholesterolemia","year":2020,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":764,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Chicoutimi","funders":"Massachusetts Medical Society; Regeneron Pharmaceuticals","keywords":"Familial hypercholesterolemia; Internal medicine; Null allele; Null (SQL); Endocrinology; LDL receptor; Medicine; PCSK9; Cholesterol; Lipoprotein; Ldl cholesterol; Gene; Biology; Genetics; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004168989,0.0003319106,0.0007235183,0.0001422606,0.0002058441,0.0002608469,0.000177591,0.000454834,0.002823625],"category_scores_gemma":[0.0003008004,0.0001333992,0.0003772732,0.0001365591,0.0002140649,0.0001269326,0.000121789,0.0005450127,0.0003134568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002033481,"about_ca_system_score_gemma":0.0002294358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000231867,"about_ca_topic_score_gemma":0.0008662472,"domain_scores_codex":[0.9998702,0.00005130027,0.00001357204,0.00002097647,0.00001941792,0.00002448567],"domain_scores_gemma":[0.999854,0.00003948663,0.00005144696,0.000005553607,0.000006790555,0.00004274297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.3899835,0.006847959,0.0536738,0.004000187,0.003986587,0.002351595,0.0001596872,0.001030379,0.0851694,0.001444706,0.009189105,0.4421631],"study_design_scores_gemma":[0.5122775,0.1565429,0.2483388,0.001045939,0.004278768,0.01464066,0.0002226996,0.002943451,0.02433061,0.001699762,0.03358316,0.00009571952],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748267,0.02102954,0.0004928705,0.0005927377,0.0001812334,0.0001852507,0.0001713555,0.00007024372,0.002450008],"genre_scores_gemma":[0.9939067,0.003034268,0.0007489579,0.0006534308,0.0001759303,0.0001578407,0.0002477489,0.000006600062,0.001068575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002823625,"threshold_uncertainty_score":0.009445965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04030542860642669,"score_gpt":0.2954700934863164,"score_spread":0.2551646648798896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}