{"id":"W3062111874","doi":"10.1371/journal.pgen.1008906","title":"Epistatic interactions between killer immunoglobulin-like receptors and human leukocyte antigen ligands are associated with ankylosing spondylitis","year":2020,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Diamantina Institute, University of Queensland; National Institutes of Health; Universidade Nova de Lisboa; University of Oxford; Vrije Universiteit Amsterdam; National Health and Medical Research Council; Brigham and Women's Hospital; Queensland University of Technology; Universitetet i Oslo; University of Melbourne; University of Toronto; Memorial University of Newfoundland; Institut National de la Santé et de la Recherche Médicale; Laboratoire d'Excellence Inflamex; National Institute for Health and Care Research; University of Alberta; Medical Research Council; Children’s Hospital of Wisconsin Research Institute; University of Texas Health Science Center at Houston; Murdoch Children's Research Institute; University of Otago; Terveyden ja hyvinvoinnin laitos; State Government of Victoria; Australian Government","keywords":"Biology; Human leukocyte antigen; Immunology; Haplotype; Allele; Population; Major histocompatibility complex; Nonsynonymous substitution; Genetics; Immune system; HLA-B Antigens; Antigen; Gene; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00007682545,0.0002411706,0.00035324,0.00009244405,0.0004160535,0.00006157505,0.0001257921,0.0001712836,0.00142468],"category_scores_gemma":[0.00009319646,0.0002276805,0.00006633143,0.0002008239,0.0001601575,0.0001233573,0.00007638454,0.0004644706,0.0002103218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008066745,"about_ca_system_score_gemma":0.00003275238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001989212,"about_ca_topic_score_gemma":0.00002258603,"domain_scores_codex":[0.9987565,0.0001412389,0.0003820943,0.0003480718,0.00006120066,0.0003108421],"domain_scores_gemma":[0.9991993,0.0001378497,0.0002668433,0.00019032,0.0001494379,0.00005620208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005107009,0.0003384466,0.201963,0.00007884565,0.00221655,0.0000183675,0.004408679,0.00003320542,0.7637404,0.0000381455,0.02509345,0.001560234],"study_design_scores_gemma":[0.003081276,0.001567859,0.1009671,0.0004473489,0.0005242252,0.00005167342,0.002249083,0.0001325445,0.5037709,0.00002763866,0.3863606,0.0008197281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960441,0.001168406,0.000117652,0.0005315175,0.001235393,0.0002219209,0.00003667129,0.0001364353,0.0005079156],"genre_scores_gemma":[0.9940958,0.0001516613,0.00005648465,0.0004882763,0.00007812135,0.00001090487,0.00105596,0.00004226839,0.004020548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3612672,"threshold_uncertainty_score":0.9994882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03114715662308765,"score_gpt":0.2428932707724736,"score_spread":0.211746114149386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}