{"id":"W3062111874","doi":"10.1371/journal.pgen.1008906","title":"Epistatic interactions between killer immunoglobulin-like receptors and human leukocyte antigen ligands are associated with ankylosing spondylitis","year":2020,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Diamantina Institute, University of Queensland; National Institutes of Health; Universidade Nova de Lisboa; University of Oxford; Vrije Universiteit Amsterdam; National Health and Medical Research Council; Brigham and Women's Hospital; Queensland University of Technology; Universitetet i Oslo; University of Melbourne; University of Toronto; Memorial University of Newfoundland; Institut National de la Santé et de la Recherche Médicale; Laboratoire d'Excellence Inflamex; National Institute for Health and Care Research; University of Alberta; Medical Research Council; Children’s Hospital of Wisconsin Research Institute; University of Texas Health Science Center at Houston; Murdoch Children's Research Institute; University of Otago; Terveyden ja hyvinvoinnin laitos; State Government of Victoria; Australian Government","keywords":"Biology; Human leukocyte antigen; Immunology; Haplotype; Allele; Population; Major histocompatibility complex; Nonsynonymous substitution; Genetics; Immune system; HLA-B Antigens; Antigen; Gene; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009179517,0.0006743441,0.0005902033,0.00149542,0.0004825545,0.0005536959,0.000480113,0.0004850805,0.002188446],"category_scores_gemma":[0.002668512,0.000348048,0.001078741,0.001877731,0.0005467474,0.0002165319,0.0006215865,0.0005696127,0.0001767013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002409445,"about_ca_system_score_gemma":0.000265599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003169971,"about_ca_topic_score_gemma":0.003596016,"domain_scores_codex":[0.9977294,0.001067843,0.000231105,0.0005313777,0.0002618208,0.000178611],"domain_scores_gemma":[0.9980491,0.0007615353,0.0006647806,0.0001844432,0.0001134933,0.0002266633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001582592,0.00008471245,0.9625325,0.0000518321,0.001270031,0.001349377,0.000212868,0.0004553426,0.02479791,0.0002291485,0.0002011106,0.007232623],"study_design_scores_gemma":[0.00002666304,0.0001735841,0.9953126,0.000005699663,0.0003418018,0.001837975,0.0001150523,0.001237304,0.0006336943,0.0001360743,0.0001660722,0.00001344978],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989389,0.0001780577,0.0005592791,0.00002741392,0.000003894633,0.000004529087,0.0001108635,0.00001374364,0.0001632264],"genre_scores_gemma":[0.9993765,0.00005257681,0.0003266311,0.00001226033,0.000007598341,0.000003645738,0.0001137055,0.000005273084,0.0001018364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003169971,"threshold_uncertainty_score":0.00732106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03114715662308765,"score_gpt":0.2428932707724736,"score_spread":0.211746114149386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}