{"id":"W3062793978","doi":"10.1200/po.19.00301","title":"Mutation Rates in Cancer Susceptibility Genes in Patients With Breast Cancer With Multiple Primary Cancers","year":2020,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Environmental Health Sciences; National Cancer Institute","keywords":"Breast cancer; Medicine; Cancer; Oncology; Germline mutation; Internal medicine; Mutation; PALB2; Mutation rate; Genetics; Biology; Population; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004381496,0.000235365,0.0003814244,0.001202045,0.0003674655,0.0005106197,0.0003029252,0.0004891043,0.002120989],"category_scores_gemma":[0.002481033,0.0001793184,0.0002918377,0.0009254823,0.0002364614,0.0002987592,0.0003978532,0.0003560621,0.0002220246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002381329,"about_ca_system_score_gemma":0.0001617298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00280721,"about_ca_topic_score_gemma":0.002567112,"domain_scores_codex":[0.9995084,0.00007491383,0.00005467793,0.0002166705,0.00008278788,0.00006257889],"domain_scores_gemma":[0.9986535,0.0003495666,0.0006098533,0.0001196014,0.0001169166,0.0001504857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001322154,0.000009966207,0.9977017,0.000006965242,0.00003774927,0.0001336675,0.00002887712,0.00003672846,0.0006816476,0.00001277998,0.00008036146,0.001137347],"study_design_scores_gemma":[0.00001358468,0.0000650553,0.997054,0.000005341842,0.00004421324,0.001969033,0.00007636843,0.0001688858,0.0003594403,0.00005563233,0.0001845392,0.000003906573],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989429,0.000277622,0.00006154965,0.0000251978,0.000003943859,0.000003557194,0.0004760599,0.00000599345,0.0002031893],"genre_scores_gemma":[0.9993512,0.00007479384,0.0000768436,0.00001639838,0.000006024025,0.000003909223,0.0003998738,0.00000238321,0.00006844657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00280721,"threshold_uncertainty_score":0.007095456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01344799936803707,"score_gpt":0.2962300911208756,"score_spread":0.2827820917528385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}