{"id":"W3064306546","doi":"10.1158/1078-0432.ccr-20-2081","title":"Biomarkers of Osimertinib Response in Patients with Refractory, EGFR-T790M–positive Non–Small Cell Lung Cancer and Central Nervous System Metastases: The APOLLO Study","year":2020,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Power Generation","funders":"Key Technology Research and Development Program of Shandong; Shandong Academy of Medical Sciences; Shandong First Medical University; AstraZeneca","keywords":"Osimertinib; T790M; Medicine; Internal medicine; Lung cancer; Oncology; Adverse effect; Cancer; Erlotinib; Epidermal growth factor receptor; Adenocarcinoma; ROS1","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001797599,0.0007374497,0.0006468678,0.0002377545,0.0002571437,0.001191417,0.0004837388,0.0005812603,0.001088577],"category_scores_gemma":[0.001918811,0.0003247533,0.0007044486,0.0003456107,0.0005035467,0.0008139668,0.0005043456,0.0009525646,0.0003048198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000819313,"about_ca_system_score_gemma":0.0007060035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005816918,"about_ca_topic_score_gemma":0.0009854353,"domain_scores_codex":[0.9994848,0.0002203469,0.00003658416,0.0001509973,0.00006223775,0.00004512176],"domain_scores_gemma":[0.9984111,0.0003385796,0.0007037441,0.000148534,0.0001387193,0.0002592248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1681141,0.003794387,0.7647569,0.0006871595,0.00289393,0.0002856515,0.0002746238,0.0008001404,0.008015262,0.000355964,0.004172667,0.0458493],"study_design_scores_gemma":[0.05556514,0.04472265,0.8734307,0.0001690238,0.004025063,0.001071906,0.0002994849,0.005917481,0.004367084,0.0007789554,0.009538325,0.0001142953],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961711,0.001607763,0.0001730068,0.0001864293,0.00003936527,0.0001826861,0.0005763264,0.000008335302,0.001055079],"genre_scores_gemma":[0.997287,0.0003820429,0.0002984957,0.0002398057,0.0001008252,0.0002231739,0.0009105135,0.00000456617,0.0005536996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001797599,"threshold_uncertainty_score":0.009506762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07101337098720283,"score_gpt":0.4553608561745889,"score_spread":0.3843474851873861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}