{"id":"W3065139950","doi":"10.7554/elife.58622","title":"The dynamic nature of the human origin recognition complex revealed through five cryoEM structures","year":2020,"lang":"en","type":"article","venue":"eLife","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; National Academies of Sciences, Engineering, and Medicine; Howard Hughes Medical Institute","keywords":"Origin recognition complex; Origin of replication; Helicase; DNA; Biology; Computational biology; DNA replication; Genetics; Eukaryotic DNA replication; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007872284,0.0001065101,0.0001001115,0.000004305823,0.0001680004,0.00001477143,0.0003249474,0.0001508183,0.00002807855],"category_scores_gemma":[0.0001386459,0.00006432577,0.000102012,0.00007410468,0.00008408805,0.000002337413,0.0001343179,0.0001856576,0.000005561535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009033714,"about_ca_system_score_gemma":0.0000334055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009045261,"about_ca_topic_score_gemma":0.000040269,"domain_scores_codex":[0.9992359,0.00009370916,0.0001599954,0.0002092105,0.0001693016,0.0001319382],"domain_scores_gemma":[0.9994338,0.00001412309,0.0001194784,0.0003129226,0.00008891621,0.00003075987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003487064,0.000008927254,0.000116183,0.00001715684,0.0000503235,7.685667e-7,0.0001480981,0.00001194519,0.9867117,0.0009822561,0.01135645,0.0005613163],"study_design_scores_gemma":[0.0005470281,0.0002100003,0.007144052,0.00001931137,0.00003774815,0.00000769863,0.0003071036,0.0001744003,0.9191937,0.005160423,0.06700363,0.0001949014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965897,0.000447358,0.0001424016,0.001346909,0.0001875225,0.0002437451,0.00006993693,0.00001738009,0.0009550675],"genre_scores_gemma":[0.996329,0.00007012633,0.0008410937,0.002153499,0.0001737441,0.000008596517,0.0001201028,0.0000163136,0.0002874918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.067518,"threshold_uncertainty_score":0.2623129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0212450059454618,"score_gpt":0.2883955613403825,"score_spread":0.2671505553949207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}