{"id":"W3065844079","doi":"","title":"Antitumor efficacy of DX-2400, a potent and selective human antibody MMP-14 inhibitor discovered using phage display technology","year":2007,"lang":"en","type":"article","venue":"","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Matrix metalloproteinase; Cancer; Phage display; Chemistry; Cancer research; Antibody; Pharmacology; Proteolysis; Toxicity; Enzyme; Immunology; Medicine; Biochemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001463946,0.0002758363,0.0002819136,0.0001541213,0.00005658437,0.0001981084,0.0001446553,0.0001971211,0.0007339365],"category_scores_gemma":[0.00009349165,0.0001045757,0.0001362157,0.00009335873,0.0001207257,0.00009785853,0.00009753313,0.0003353051,0.0001603904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001910014,"about_ca_system_score_gemma":0.0001528326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004339507,"about_ca_topic_score_gemma":0.0003760506,"domain_scores_codex":[0.9999396,0.00001184568,0.000004946621,0.00001265904,0.0000152179,0.00001580789],"domain_scores_gemma":[0.9999659,0.000008845236,0.000006310395,0.000003080452,0.000004097412,0.00001177876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003945054,0.0001241015,0.0003932522,0.00005580627,0.000006921059,0.00003112447,0.00001082993,0.000276677,0.9933008,0.00007516727,0.00008359884,0.005247211],"study_design_scores_gemma":[0.00007969705,0.004154302,0.003337731,0.000004627771,0.0000302874,0.0002922462,0.000006061022,0.001566653,0.9886596,0.00002520167,0.001839365,0.000004220149],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942904,0.002322632,0.001233365,0.00005785446,0.00002234949,0.00002476275,0.0002214622,0.00008122081,0.001745885],"genre_scores_gemma":[0.9951963,0.001161806,0.001158662,0.00002986115,0.000008236279,0.0000150454,0.0004270449,0.000007782744,0.001995363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007339365,"threshold_uncertainty_score":0.002455294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02312759841623987,"score_gpt":0.3734673294386667,"score_spread":0.3503397310224269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}