{"id":"W3066049608","doi":"10.1073/pnas.2003787117","title":"Agonist-induced formation of unproductive receptor-G <sub>12</sub> complexes","year":2020,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Institute of General Medical Sciences; National Institute of Mental Health; Canadian Institutes of Health Research; Svenska Sällskapet för Medicinsk Forskning; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Government of Canada; Japan Agency for Medical Research and Development","keywords":"Heterotrimeric G protein; G protein-coupled receptor; Agonist; G protein; Receptor; Chemistry; G beta-gamma complex; Cell biology; Signal transduction; Ternary complex; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004981816,0.00007601024,0.0001219561,0.000039887,0.0001037242,0.00001040122,0.0004147005,0.00007395266,0.000007273584],"category_scores_gemma":[0.0003422282,0.00005554122,0.00007450567,0.0002583658,0.0002487412,0.00003469559,0.0001111494,0.00007287785,6.540357e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008279822,"about_ca_system_score_gemma":0.00002818591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001411493,"about_ca_topic_score_gemma":3.417908e-8,"domain_scores_codex":[0.9989127,0.000007368599,0.0002726353,0.0001997877,0.0005112331,0.00009626269],"domain_scores_gemma":[0.9992398,0.00001299755,0.0004213232,0.000007479796,0.0002885729,0.0000297997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002690018,0.00001527401,0.0001113853,0.00004766076,0.000009602615,4.542377e-10,0.0001739976,0.00005909024,0.9937918,0.00484064,0.0005445392,0.0003791595],"study_design_scores_gemma":[0.0001134541,0.0001537454,0.0005192147,0.00003189578,0.000005725852,0.000001164636,0.0002763727,0.0002817878,0.995166,0.00314831,0.0002409172,0.00006140699],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971768,0.00006610189,0.00002571652,0.001680939,0.00001734145,0.0001785402,0.00001678066,0.000003585874,0.0008342012],"genre_scores_gemma":[0.9985999,0.00003256924,0.001022077,0.0001935332,0.000132377,0.000006535846,0.000001348733,0.000003669461,0.000007959969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00169233,"threshold_uncertainty_score":0.2264905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04800845982450903,"score_gpt":0.2780016850944965,"score_spread":0.2299932252699874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}