{"id":"W3066049608","doi":"10.1073/pnas.2003787117","title":"Agonist-induced formation of unproductive receptor-G <sub>12</sub> complexes","year":2020,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Institute of General Medical Sciences; National Institute of Mental Health; Canadian Institutes of Health Research; Svenska Sällskapet för Medicinsk Forskning; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Government of Canada; Japan Agency for Medical Research and Development","keywords":"Heterotrimeric G protein; G protein-coupled receptor; Agonist; G protein; Receptor; Chemistry; G beta-gamma complex; Cell biology; Signal transduction; Ternary complex; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000418111,0.0002807892,0.0003052226,0.000232481,0.0001958972,0.000565643,0.0002739269,0.0003345681,0.004864402],"category_scores_gemma":[0.0004593182,0.0002216572,0.0003463282,0.0001506717,0.0003271617,0.0002382103,0.0004457083,0.0009628948,0.001148008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005189118,"about_ca_system_score_gemma":0.0003566868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004664411,"about_ca_topic_score_gemma":0.0006080878,"domain_scores_codex":[0.9995044,0.00009327552,0.00005338162,0.00007848402,0.0001322378,0.0001381405],"domain_scores_gemma":[0.9995332,0.0001238373,0.00007572617,0.00009641702,0.00005548583,0.0001152544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003083097,0.00008042792,0.000260752,0.00005811077,0.00001272943,0.00012357,0.00001995018,0.00006496527,0.9973344,0.0003919819,0.0001956423,0.001149258],"study_design_scores_gemma":[0.00003318767,0.000331114,0.009028368,0.00001131157,0.00001377311,0.0005270237,0.00003690919,0.0008218992,0.9854025,0.0002190631,0.003565378,0.000009492924],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863386,0.002835715,0.002719582,0.0003854636,0.0001845667,0.00007799394,0.00069372,0.0001111274,0.006653332],"genre_scores_gemma":[0.9906218,0.00064598,0.002020802,0.0003497075,0.00002859808,0.00006157036,0.0007804902,0.00003392154,0.00545729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004864402,"threshold_uncertainty_score":0.01627302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04800845982450903,"score_gpt":0.2780016850944965,"score_spread":0.2299932252699874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}