{"id":"W3066725994","doi":"10.1186/s12885-020-07273-7","title":"Breast cancer mammospheres secrete Adrenomedullin to induce lipolysis and browning of adjacent adipocytes","year":2020,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Institut National de la Santé et de la Recherche Médicale; Institut National Du Cancer; Canceropôle PACA; Centre National de la Recherche Scientifique; China Scholarship Council; Agence Nationale de la Recherche; Fondation ARC pour la Recherche sur le Cancer; Fonds de Recherche du Québec-Société et Culture; Fonds de Recherche du Québec - Santé; Fondation du cancer du sein du Québec; Joslin Diabetes Center; Association pour la Recherche sur le Cancer","keywords":"Paracrine signalling; Adipocyte; Lipolysis; Cancer research; Adipokine; Cancer cell; Internal medicine; Adipose tissue; Stromal cell; Adrenomedullin; Endocrinology; Lipid droplet; Cancer; Biology; Cell biology; Chemistry; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00005811271,0.0001760763,0.0004696929,0.00004180953,0.00003852453,0.00001119241,0.00008495355,0.00007696317,0.001872164],"category_scores_gemma":[0.00003956337,0.0001526848,0.00007455243,0.0003421322,0.00005579503,0.00006406016,0.00007875483,0.0001433047,0.00001879674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005069805,"about_ca_system_score_gemma":0.0002738141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002529371,"about_ca_topic_score_gemma":0.000716508,"domain_scores_codex":[0.9988733,0.00002508696,0.0002617483,0.0003342716,0.0002363371,0.0002692553],"domain_scores_gemma":[0.9991357,0.00003123381,0.0001008864,0.0001800399,0.0001101258,0.0004419859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.002480521,0.0001099516,0.3447586,0.001447849,0.0009232348,0.00003619973,0.01261287,0.0007480142,0.1823922,0.0002738436,0.01487397,0.4393428],"study_design_scores_gemma":[0.004608865,0.0003780173,0.6918677,0.001365803,0.001932648,0.00008473259,0.001356488,0.0009402505,0.1287366,0.00002184059,0.1679259,0.0007811165],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9562491,0.03874478,0.0002029415,0.003754664,0.0001719902,0.0003583844,0.0001472001,0.0000441116,0.0003268586],"genre_scores_gemma":[0.99198,0.001876011,0.001830132,0.002050558,0.0009627358,0.00008686929,0.000006774322,0.00003954754,0.001167342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4385616,"threshold_uncertainty_score":0.9990402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03479685210441151,"score_gpt":0.2944123602545917,"score_spread":0.2596155081501801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}