{"id":"W3068150758","doi":"10.1038/s41419-020-02893-0","title":"Shedding of cancer susceptibility candidate 4 by the convertases PC7/furin unravels a novel secretory protein implicated in cancer progression","year":2020,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Université de Montréal; Montreal Clinical Research Institute","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Canada Research Chairs; Government of Canada","keywords":"Furin; Proprotein Convertases; Biology; Cell biology; Transmembrane protein; Transfection; Proprotein convertase; Cancer cell; Endosome; HEK 293 cells; Signal transducing adaptor protein; Cell culture; Cancer; Molecular biology; Biochemistry; Signal transduction; Genetics; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008223554,0.0002827907,0.0001803766,0.0002445569,0.0001276523,0.0002640235,0.0001318536,0.0002320362,0.0006833845],"category_scores_gemma":[0.00007024207,0.00009915612,0.0003208811,0.0001361344,0.0001196627,0.0001719099,0.0001582169,0.0003645838,0.00023064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000304082,"about_ca_system_score_gemma":0.0001719164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005738906,"about_ca_topic_score_gemma":0.0004914255,"domain_scores_codex":[0.9999472,0.00000567162,0.000004443613,0.00001052392,0.00001858197,0.00001363247],"domain_scores_gemma":[0.9999495,0.00000641917,0.00001502133,0.000004745991,0.00001044969,0.00001385498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006739354,0.000007973016,0.0009829648,0.00002344969,0.000006092683,0.0001821284,0.000009282617,0.00005094583,0.9975663,0.00006540595,0.00003830484,0.000999678],"study_design_scores_gemma":[0.00001427348,0.0002160989,0.0206005,0.00001032832,0.00006673472,0.002170089,0.00008883273,0.003916139,0.9669557,0.0002163979,0.005734792,0.00001003782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955667,0.001466985,0.00208775,0.0001091363,0.00001709329,0.00001427308,0.0002567329,0.00003348273,0.0004477608],"genre_scores_gemma":[0.9938135,0.001089265,0.002576295,0.00006934462,0.00001126268,0.0000109822,0.0006747819,0.0000109417,0.001743574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006833845,"threshold_uncertainty_score":0.002286196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01329775295831185,"score_gpt":0.2661137505445704,"score_spread":0.2528159975862586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}