{"id":"W3068359420","doi":"10.2147/pgpm.s261208","title":"&lt;p&gt;IL-6 −572C&gt;G and CARD8 304T&gt;A Genetic Polymorphisms are Associated with the Absolute Neutrophil Count in Patients with Hematological Malignancies Under Chemotherapy: An Application of Multilevel Models to a Preliminary Pharmacogenetic Study&lt;/p&gt;","year":2020,"lang":"en","type":"article","venue":"Pharmacogenomics and Personalized Medicine","topic":"Inflammatory Biomarkers in Disease Prognosis","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Impact; McMaster University; Population Health Research Institute","funders":"Universidad de Chile","keywords":"Medicine; Internal medicine; Gastroenterology; Chemotherapy; Absolute neutrophil count; Genotype; Neutropenia; Oncology; Acute leukemia; Leukemia; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004112449,0.0005177158,0.0009425462,0.00015444,0.0001614209,0.00002101464,0.0002411139,0.0001138227,0.00005399168],"category_scores_gemma":[0.00002411322,0.0003385606,0.00006618007,0.0003625559,0.0005310863,0.0000825215,0.0001037558,0.0002144947,0.000001290363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001292127,"about_ca_system_score_gemma":0.000138467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002208817,"about_ca_topic_score_gemma":0.00001839131,"domain_scores_codex":[0.9971894,0.0001945329,0.0006001617,0.0008040635,0.0007429469,0.0004688977],"domain_scores_gemma":[0.9982734,0.0001311238,0.0003955484,0.0003008815,0.0003131441,0.0005859506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.06864996,0.004802083,0.4837293,0.00121642,0.003991921,0.0004661737,0.03865047,0.002093137,0.3842098,0.0001620165,0.001215432,0.01081323],"study_design_scores_gemma":[0.03862967,0.004356605,0.8971392,0.0004198802,0.002295043,0.00005334454,0.001170549,0.05324709,0.001246064,0.00003898353,0.0007127658,0.0006908114],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874573,0.004237855,0.0005650597,0.003936405,0.00003605727,0.003489806,0.0002016251,0.00005198072,0.00002393975],"genre_scores_gemma":[0.9934799,0.0005660822,0.0004510179,0.00480902,0.0001182487,0.0003828334,0.00008975634,0.00008992483,0.00001322907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4134099,"threshold_uncertainty_score":0.9999067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03032901294697899,"score_gpt":0.2638131900072627,"score_spread":0.2334841770602837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}