{"id":"W307046337","doi":"10.1007/s12035-015-9173-7","title":"Treatment with Trehalose Prevents Behavioral and Neurochemical Deficits Produced in an AAV α-Synuclein Rat Model of Parkinson’s Disease","year":2015,"lang":"en","type":"article","venue":"Molecular Neurobiology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":129,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital; University Health Network","funders":"Science and Technology Commission of Shanghai Municipality; SLAC National Accelerator Laboratory; Fudan University","keywords":"Neurochemical; Parkinson's disease; Trehalose; Neurodegeneration; Dopaminergic; Dopamine; Neuroscience; Autophagy; Alpha-synuclein; Striatum; Monoamine neurotransmitter; Neurotoxicity; Biology; Medicine; Disease; Biochemistry; Internal medicine; Serotonin; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000403098,0.0002828556,0.000439799,0.0001256578,0.00001981609,0.000007752648,0.00007591996,0.00008358416,0.000003135525],"category_scores_gemma":[0.00001823761,0.0002154854,0.00006647803,0.0001126031,0.00009171307,0.00005609326,0.00005044871,0.00009083978,0.000002387631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007346325,"about_ca_system_score_gemma":0.0001905926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000291259,"about_ca_topic_score_gemma":0.00001275203,"domain_scores_codex":[0.9985184,0.0001491013,0.0002376483,0.0006502844,0.0001370967,0.0003074554],"domain_scores_gemma":[0.9989182,0.000009298924,0.0000811826,0.0004277414,0.00005685852,0.0005067568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004936507,0.005803301,0.2428518,0.0000510713,0.00006114875,0.002599834,0.0002252921,0.0003187895,0.7409116,0.00008810413,0.00001145843,0.002141029],"study_design_scores_gemma":[0.04865525,0.03952656,0.1263947,0.0002158443,0.002790466,0.0006032207,0.0001154044,0.019156,0.7592932,0.0009321183,0.0009855628,0.001331679],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986823,0.0001988927,0.00004167728,0.0001685048,0.00003706226,0.0007624812,0.00004929642,0.00003414252,0.00002563124],"genre_scores_gemma":[0.9988617,0.00002532713,0.0006181755,0.0001509622,0.00001011522,0.0001134493,0.0001389065,0.00004319856,0.00003819721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1164572,"threshold_uncertainty_score":0.8787241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03692932150411123,"score_gpt":0.2843822221797403,"score_spread":0.2474529006756291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}