{"id":"W3070585844","doi":"10.1038/s41419-020-02907-x","title":"Chemotherapeutic resistance of head and neck squamous cell carcinoma is mediated by EpCAM induction driven by IL-6/p62 associated Nrf2-antioxidant pathway activation","year":2020,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; McGill University","funders":"Biomedical Research Council; Medical Research Council; World Bank Group","keywords":"Epithelial cell adhesion molecule; Gene silencing; Cancer research; Head and neck squamous-cell carcinoma; Cisplatin; Small interfering RNA; Biology; Gene knockdown; Molecular biology; Chemistry; Cell culture; Cell adhesion molecule; Cell biology; Cancer; Transfection; Head and neck cancer; Chemotherapy; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001023625,0.0001854671,0.0002223983,0.0001802961,0.00009759919,0.0001771295,0.00007040684,0.0001455239,0.001486349],"category_scores_gemma":[0.00009154113,0.0000757225,0.0002352087,0.0001094018,0.0001164593,0.0001132996,0.0001554029,0.0003018415,0.000245152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001221993,"about_ca_system_score_gemma":0.00008451209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002091637,"about_ca_topic_score_gemma":0.0002539573,"domain_scores_codex":[0.999912,0.00001521536,0.00001042786,0.00001584172,0.00002502286,0.00002152613],"domain_scores_gemma":[0.9999527,0.000007360277,0.00001363293,0.000008000218,0.00001031647,0.000007988012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001708195,0.00004693417,0.0007798121,0.00004479878,0.000007156671,0.0001233902,0.00001701677,0.00003223355,0.9970574,0.00005254889,0.00007188207,0.001596024],"study_design_scores_gemma":[0.00004211579,0.0006016707,0.04097039,0.00001138731,0.0000394558,0.0006907655,0.00008749003,0.00149252,0.9535734,0.000107846,0.002377103,0.000005880744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961649,0.001234581,0.001262058,0.00008715766,0.00001870671,0.00003475045,0.0002355999,0.00004649779,0.0009157551],"genre_scores_gemma":[0.9978406,0.0004399128,0.0004347337,0.00003480944,0.000005111567,0.0000283084,0.0001831258,0.000003678824,0.001029696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001486349,"threshold_uncertainty_score":0.004972398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01669759022869012,"score_gpt":0.2303128173019571,"score_spread":0.213615227073267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}