{"id":"W3070585844","doi":"10.1038/s41419-020-02907-x","title":"Chemotherapeutic resistance of head and neck squamous cell carcinoma is mediated by EpCAM induction driven by IL-6/p62 associated Nrf2-antioxidant pathway activation","year":2020,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; McGill University","funders":"Biomedical Research Council; Medical Research Council; World Bank Group","keywords":"Epithelial cell adhesion molecule; Gene silencing; Cancer research; Head and neck squamous-cell carcinoma; Cisplatin; Small interfering RNA; Biology; Gene knockdown; Molecular biology; Chemistry; Cell culture; Cell adhesion molecule; Cell biology; Cancer; Transfection; Head and neck cancer; Chemotherapy; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005796038,0.0001968041,0.0003245887,0.00004208785,0.00007280576,0.00001965313,0.0000437433,0.00009190915,0.0001023301],"category_scores_gemma":[0.00007694273,0.0001834532,0.00007382108,0.0001921941,0.00006040497,0.00008679952,0.00002217617,0.000130257,0.00000448022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005345762,"about_ca_system_score_gemma":0.0001633035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001134644,"about_ca_topic_score_gemma":0.00000490529,"domain_scores_codex":[0.9988369,0.00004567866,0.0002616655,0.0003863842,0.0002463726,0.0002229709],"domain_scores_gemma":[0.9988438,0.00004230328,0.0001765929,0.0001616932,0.0000876901,0.0006879015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001751973,0.0006885321,0.07224649,0.001094051,0.000042951,0.00001733845,0.000849894,0.000001181089,0.8909603,0.000005228388,0.03114802,0.001194083],"study_design_scores_gemma":[0.01531609,0.0009463094,0.2158626,0.0001683288,0.0009279996,0.000001812733,0.0004409811,0.000918491,0.7229131,0.00007334902,0.04176605,0.0006648834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896833,0.00715718,0.00006241691,0.001363865,0.00003954726,0.0003871747,0.0007131585,0.00003196363,0.0005613808],"genre_scores_gemma":[0.9959666,0.0005951488,0.00005351985,0.002010623,0.00004906356,0.00001421928,0.0003658479,0.00002914542,0.0009158598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1680471,"threshold_uncertainty_score":0.7481003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01669759022869012,"score_gpt":0.2303128173019571,"score_spread":0.213615227073267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}