{"id":"W3071189934","doi":"10.3389/fphar.2020.01266","title":"NCS 613, a Potent PDE4 Inhibitor, Displays Anti-Inflammatory and Anti-Proliferative Properties on A549 Lung Epithelial Cells and Human Lung Adenocarcinoma Explants","year":2020,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"A549 cell; Adenocarcinoma; Cancer research; Inflammation; Cell growth; p38 mitogen-activated protein kinases; MAPK/ERK pathway; Carcinogenesis; Signal transduction; Tumor necrosis factor alpha; Lung; Medicine; Biology; Immunology; Cancer; Cell biology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001284131,0.0003674217,0.0003193616,0.0002224208,0.000186159,0.0001448204,0.000174163,0.0002707418,0.001968188],"category_scores_gemma":[0.00009350395,0.0001187212,0.0003767792,0.000190013,0.0001718012,0.0001519969,0.000120295,0.0006514287,0.0003754706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002256396,"about_ca_system_score_gemma":0.0003217029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001537435,"about_ca_topic_score_gemma":0.003266895,"domain_scores_codex":[0.9999027,0.00001275408,0.00001089646,0.00001920844,0.00003419624,0.00002019548],"domain_scores_gemma":[0.999944,0.00001509178,0.00001207342,0.000006486681,0.000009502369,0.00001286635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001590257,0.00004780514,0.00008176714,0.0001127587,0.000005566722,0.00003925865,0.00001140369,0.00006288628,0.997521,0.00004062021,0.00006161997,0.001856276],"study_design_scores_gemma":[0.00003453449,0.0006251129,0.002711292,0.000008232519,0.00001792911,0.0001848027,0.00002662139,0.0003608385,0.9933229,0.00003007536,0.002673394,0.000004375066],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9670596,0.0159264,0.005959557,0.0004789305,0.0001690693,0.00009987758,0.001987728,0.0002053592,0.008113584],"genre_scores_gemma":[0.9794246,0.007400921,0.004747513,0.0001339345,0.00002800265,0.00008180775,0.002029878,0.00002336077,0.00612992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001968188,"threshold_uncertainty_score":0.006584227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0107566003955038,"score_gpt":0.2353771663829829,"score_spread":0.2246205659874791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}