{"id":"W3074819526","doi":"10.1158/1538-7445.am2020-6600","title":"Abstract 6600: Rapid generation of TCR-engineered T lymphocytes by linking the single cell transcriptome to its corresponding T cell receptor in antigen specific T cells","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"MD Precision (Canada)","funders":"","keywords":"T-cell receptor; Biology; clone (Java method); Transcriptome; CD8; T cell; Cytotoxic T cell; Molecular biology; Cell biology; Population; Cell; Antigen; Immunology; In vitro; Gene expression; Gene; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001533252,0.0002579607,0.0002008279,0.0001255332,0.00009332179,0.0003358747,0.0001527835,0.0002230177,0.001229204],"category_scores_gemma":[0.00009428137,0.0001432506,0.0001745342,0.0001736678,0.0001246044,0.00013011,0.0002292834,0.000537345,0.0008750311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008654305,"about_ca_system_score_gemma":0.00009359271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009715374,"about_ca_topic_score_gemma":0.0001528158,"domain_scores_codex":[0.9998587,0.0000122976,0.000009534327,0.00004390259,0.00004906534,0.00002642841],"domain_scores_gemma":[0.9999448,0.000007549745,0.00001806773,0.00000850432,0.000008418599,0.00001256622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001564109,0.000004150766,0.00006124915,0.000007700169,9.674295e-7,0.000006969114,0.000003751132,0.00003682146,0.9993404,0.00002261689,0.00001937091,0.0004804201],"study_design_scores_gemma":[0.00001086533,0.0001441418,0.002493612,0.000004192424,0.00001145696,0.0001190132,0.00001525156,0.002503368,0.9919279,0.00006363927,0.002702357,0.000004134964],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9556444,0.000448937,0.04055732,0.00006360707,0.00006654404,0.00007552346,0.001219944,0.0004016366,0.001522113],"genre_scores_gemma":[0.9575938,0.0005651556,0.03229231,0.0001177928,0.00002537767,0.0001513993,0.003141684,0.000245369,0.00586715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001229204,"threshold_uncertainty_score":0.004112065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1487216237679269,"score_gpt":0.3563254740094948,"score_spread":0.2076038502415679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}