{"id":"W3074876817","doi":"10.1039/d0cb00086h","title":"Sub-stoichiometric inhibition of IAPP aggregation: a peptidomimetic approach to anti-amyloid agents","year":2020,"lang":"en","type":"article","venue":"RSC Chemical Biology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"York University; New York University Abu Dhabi; New York University","keywords":"Peptidomimetic; Amyloid (mycology); Chemistry; Stoichiometry; Amyloid β; Biochemistry; Organic chemistry; Medicine; Internal medicine; Peptide","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006550594,0.0001463299,0.0003890585,0.0001961803,0.00002607244,0.000004809655,0.00008066164,0.0001331424,0.0001095441],"category_scores_gemma":[0.000430714,0.0001188104,0.0001291239,0.001070807,0.0001265835,0.00002724076,0.00009431388,0.0001415641,0.0002107395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000532752,"about_ca_system_score_gemma":0.00008072597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001055024,"about_ca_topic_score_gemma":6.449584e-8,"domain_scores_codex":[0.9988103,0.00004944649,0.0002631535,0.0003755103,0.0002018706,0.0002997306],"domain_scores_gemma":[0.9990323,0.00007944703,0.00006497878,0.0001788779,0.0001040868,0.0005402623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001004185,0.001833102,0.04980254,0.0003172087,0.00240156,0.00005371594,0.0001878497,0.000002346227,0.9339116,0.0002966951,0.003098624,0.007090589],"study_design_scores_gemma":[0.005207577,0.001113892,0.01697147,0.00006884879,0.0004235107,0.00004278779,0.00004910338,0.0003731289,0.9745494,0.0002119989,0.0007348597,0.0002534256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949495,0.001265067,0.0002172573,0.0009549116,0.00001998075,0.0005250443,0.00006667781,0.00004370506,0.00195792],"genre_scores_gemma":[0.9976162,0.00007448104,0.0009032987,0.0006049664,0.0001400761,0.00004535469,0.0005948347,0.00001523702,0.00000558944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04063782,"threshold_uncertainty_score":0.4844947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04379595909852716,"score_gpt":0.3066077732062297,"score_spread":0.2628118141077025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}