{"id":"W3076961298","doi":"10.1111/febs.15503","title":"Allovalency observed by transferred NOE: interactions of sulfated tyrosine residues in the N‐terminal segment of CCR5 with the CCL5 chemokine","year":2020,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); Hospital for Sick Children; University of Toronto","funders":"Minerva Foundation","keywords":"Sulfation; Chemistry; CCL5; Chemokine receptor; Tyrosine; Chemokine; Biochemistry; Ligand (biochemistry); CC chemokine receptors; Stereochemistry; Receptor; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002939197,0.00009146281,0.0001242945,0.00002913486,0.00006512256,0.00002248367,0.0002927746,0.00004227974,0.0001128441],"category_scores_gemma":[0.00005973229,0.00004984465,0.0000687143,0.000196133,0.00008737421,0.000007714973,0.00002645385,0.0002585947,0.000001030865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008787045,"about_ca_system_score_gemma":0.00007816933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003409373,"about_ca_topic_score_gemma":0.0001006812,"domain_scores_codex":[0.999049,0.000151059,0.0002644865,0.0001158685,0.0002761517,0.0001434107],"domain_scores_gemma":[0.9995126,0.00002006987,0.0001058531,0.0001535781,0.0001541227,0.00005380581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008714731,0.0001506055,0.002032819,0.00002972568,0.00005740488,0.00001511977,0.0006742358,0.00008411294,0.9883684,0.000007348508,0.006409562,0.001299182],"study_design_scores_gemma":[0.00232127,0.001254784,0.02873937,0.00007840544,0.00003124708,0.0002030022,0.0009657887,0.0002111155,0.9493922,0.00001114633,0.0166697,0.0001219923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883562,0.000523946,0.0008661005,0.009746181,0.00001954279,0.00019871,0.00003058647,0.000001882262,0.000256802],"genre_scores_gemma":[0.9990622,0.0002196511,0.0001397781,0.0002376506,0.00008268204,0.000008215999,0.00003925673,0.000008777242,0.0002018165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03897623,"threshold_uncertainty_score":0.2032606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03355350288844729,"score_gpt":0.2785296018212165,"score_spread":0.2449760989327692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}