{"id":"W3076961298","doi":"10.1111/febs.15503","title":"Allovalency observed by transferred NOE: interactions of sulfated tyrosine residues in the N‐terminal segment of CCR5 with the CCL5 chemokine","year":2020,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); Hospital for Sick Children; University of Toronto","funders":"Minerva Foundation","keywords":"Sulfation; Chemistry; CCL5; Chemokine receptor; Tyrosine; Chemokine; Biochemistry; Ligand (biochemistry); CC chemokine receptors; Stereochemistry; Receptor; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002180896,0.0003723701,0.0001608316,0.00006626709,0.0001084314,0.0001577794,0.0002579862,0.0002416428,0.000894987],"category_scores_gemma":[0.0003175981,0.0001207745,0.0001456726,0.00009346972,0.0002671515,0.0002081985,0.0002404108,0.0005001716,0.0001627029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000155146,"about_ca_system_score_gemma":0.0000948059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000289899,"about_ca_topic_score_gemma":0.0003374364,"domain_scores_codex":[0.9998454,0.00003941826,0.000006069577,0.00002788708,0.00003949917,0.00004178231],"domain_scores_gemma":[0.9998025,0.00004898544,0.0000651448,0.00001992466,0.00002642526,0.00003695795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001949369,0.00003094583,0.0002818527,0.00002585993,0.00001298756,0.0000419428,0.00002025405,0.00007704543,0.9986923,0.00005421009,0.00001546207,0.0005522605],"study_design_scores_gemma":[0.00001377529,0.0004111779,0.005299982,0.000003732018,0.00001237637,0.0001603931,0.00003305939,0.001316108,0.99212,0.00004088242,0.0005828615,0.000005649595],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982089,0.0002721706,0.0008781405,0.00003664148,0.0000171484,0.000008463277,0.00002772028,0.000009339438,0.0005414225],"genre_scores_gemma":[0.9984604,0.0001648634,0.0006213369,0.00006304889,0.000006273134,0.000009347104,0.00007162215,0.000005201246,0.0005978935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000894987,"threshold_uncertainty_score":0.002994061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03355350288844729,"score_gpt":0.2785296018212165,"score_spread":0.2449760989327692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}