{"id":"W3077250840","doi":"10.1039/d0np00028k","title":"Chemical syntheses of the salvinorin chemotype of KOR agonist","year":2020,"lang":"en","type":"review","venue":"Natural Product Reports","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Chemistry; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada","keywords":"Chemotype; Chemical space; Agonist; Chemistry; Drug discovery; Receptor; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001982381,0.0003388355,0.001316556,0.00002624168,0.00003044599,0.00001062777,0.0004204597,0.0002693764,0.00002768283],"category_scores_gemma":[0.002705179,0.0001983064,0.001234314,0.0003157501,0.0002087457,0.000002043201,0.0003900191,0.0003241586,0.000001310626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002525849,"about_ca_system_score_gemma":0.0002641811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002076666,"about_ca_topic_score_gemma":0.000001530316,"domain_scores_codex":[0.9978037,0.00006711085,0.000914946,0.0007066404,0.0003149711,0.0001925725],"domain_scores_gemma":[0.9976085,0.00004255955,0.001110153,0.001031037,0.0001457976,0.00006196248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001170373,0.0000758635,0.00003951934,0.005171213,0.0004836371,0.00001436099,0.000004595797,1.353923e-7,0.2104236,0.00000599206,0.001669908,0.7820994],"study_design_scores_gemma":[0.00001199824,0.000007487259,0.000004068817,0.0008822288,0.0004714523,0.0001082505,0.000001143211,1.755281e-7,0.3904133,0.000005627355,0.6079406,0.000153643],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002273331,0.9964287,4.286302e-7,0.0001095094,0.0002478324,0.000306483,0.00002267344,0.000007691729,0.000603398],"genre_scores_gemma":[0.2111343,0.7875124,0.0001085289,0.00001630017,0.0006017663,0.00001434561,0.0001160008,0.00003977699,0.0004565278],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7819458,"threshold_uncertainty_score":0.8086702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0166463176823897,"score_gpt":0.277364564286436,"score_spread":0.2607182466040463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}