{"id":"W3078005693","doi":"10.1080/07391102.2020.1808076","title":"Locating the binding sites of two aminobenzoic acid derivatives on tRNA: drug binding efficacy and RNA structure","year":2020,"lang":"en","type":"article","venue":"Journal of Biomolecular Structure and Dynamics","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières; Innovation and Economic Development Trois Rivières","funders":"Natural Sciences and Engineering Research Council of Canada; Cancer Research Society","keywords":"Chemistry; Transfer RNA; Adduct; Aqueous solution; Hydrazine (antidepressant); Medicinal chemistry; Stereochemistry; RNA; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001642055,0.0002291639,0.0002979085,0.00008047329,0.0001504849,0.00006207448,0.0002365905,0.0001327413,0.00000613766],"category_scores_gemma":[0.0001918881,0.0001522343,0.00009568107,0.000166462,0.000127753,0.00001220495,0.0001056276,0.0002359095,1.41743e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001185101,"about_ca_system_score_gemma":0.00004535706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002856169,"about_ca_topic_score_gemma":0.000007541702,"domain_scores_codex":[0.9988459,0.0001242458,0.0003722638,0.0002356683,0.0002387726,0.0001831897],"domain_scores_gemma":[0.9990659,0.00004543519,0.0005017061,0.0001670668,0.0001007961,0.0001191051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001368667,0.000008757591,0.0006467641,0.00005428747,0.0001340248,0.00001406297,0.0003958228,0.00008579271,0.9867181,0.0004424754,0.00001300314,0.01135008],"study_design_scores_gemma":[0.000838714,0.0005525717,0.0005523897,0.00006906003,0.00008957089,0.0001342419,0.0004326564,0.0005469464,0.9960433,0.0004860759,0.00007312267,0.0001814024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905825,0.001780859,0.006804145,0.0005212507,0.0000888386,0.0001388026,0.00005798036,0.000003454424,0.00002212833],"genre_scores_gemma":[0.9956772,0.0001529916,0.003657809,0.000266837,0.0001932404,4.860348e-7,0.00002237442,0.00002286945,0.000006156112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01116867,"threshold_uncertainty_score":0.6207935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008487792695124783,"score_gpt":0.2418872620465534,"score_spread":0.2333994693514286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}