{"id":"W3079445417","doi":"10.18632/aging.103792","title":"The role of Anaphase Promoting Complex activation, inhibition and substrates in cancer development and progression","year":2020,"lang":"en","type":"review","venue":"Aging","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Anaphase; Cell biology; Cancer research; Chemistry; Cancer; Biophysics; Biology; Genetics; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003569204,0.0006872152,0.0009067138,0.002025847,0.0002368106,0.0008088802,0.0006548994,0.0007615733,0.00296337],"category_scores_gemma":[0.0005199438,0.0002091001,0.000302428,0.001828198,0.0003427789,0.00101118,0.000644631,0.00130851,0.001956596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005564356,"about_ca_system_score_gemma":0.0007784924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006631681,"about_ca_topic_score_gemma":0.001227208,"domain_scores_codex":[0.9998758,0.00001873924,0.00002214099,0.00002063808,0.00004833556,0.00001420589],"domain_scores_gemma":[0.9998416,0.0000625982,0.00002721335,0.000005291138,0.00004061624,0.00002272893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007431921,0.00004562924,0.00014684,0.01287962,0.0000657392,0.000229167,0.00004697085,0.0002683312,0.001888529,0.003017046,0.02781052,0.9535272],"study_design_scores_gemma":[0.00001436243,0.00007616106,0.000968652,0.00223931,0.00007979662,0.001499528,0.00003579732,0.0000596562,0.0004581386,0.001436986,0.9931184,0.00001325397],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009316704,0.9988182,0.00006730079,0.0001358262,0.0001544504,0.000002304269,0.00001144174,0.000006495557,0.00071085],"genre_scores_gemma":[0.0004835382,0.9987636,0.00008935414,0.00009822564,0.0001171276,0.000003798845,0.00002266114,0.000001125029,0.0004206996],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00296337,"threshold_uncertainty_score":0.009913445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02344264150681914,"score_gpt":0.3205965791466052,"score_spread":0.297153937639786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}