{"id":"W3079445417","doi":"10.18632/aging.103792","title":"The role of Anaphase Promoting Complex activation, inhibition and substrates in cancer development and progression","year":2020,"lang":"en","type":"review","venue":"Aging","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Anaphase; Cell biology; Cancer research; Chemistry; Cancer; Biophysics; Biology; Genetics; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009417281,0.0001068331,0.0001936557,0.00002299959,0.00006652057,0.00001970796,0.00003701886,0.00006804461,4.269765e-7],"category_scores_gemma":[0.00001394166,0.00007613606,0.00002014968,0.0000605898,0.0000318104,0.000002509677,0.00007117962,0.00007017858,6.414134e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001184941,"about_ca_system_score_gemma":0.000093972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001232679,"about_ca_topic_score_gemma":0.00006388597,"domain_scores_codex":[0.9994521,0.00003438918,0.0002093066,0.0001762444,0.00003897087,0.00008898651],"domain_scores_gemma":[0.9997378,0.00001150133,0.0001508889,0.00005732175,0.00002081198,0.00002167928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000002272058,0.000008790998,0.0002743685,0.001086318,0.00002121183,5.444859e-7,0.0001388192,1.27117e-7,0.01999602,0.00001035284,0.000004439507,0.9784567],"study_design_scores_gemma":[0.0001481126,0.00002794312,0.0001389985,0.004981717,0.00003129971,0.000007881012,0.0001144882,0.00005215602,0.07225638,0.00001604245,0.9220659,0.000159087],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.08881519,0.9108459,0.00001168766,0.00002533467,0.000007194254,0.0002698747,0.000004140943,0.000002308374,0.00001836549],"genre_scores_gemma":[0.0449538,0.9545764,0.0002231821,0.000009851874,0.0000322141,0.00005354382,0.0001363098,0.00001142117,0.00000328946],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9782977,"threshold_uncertainty_score":0.3104738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02344264150681914,"score_gpt":0.3205965791466052,"score_spread":0.297153937639786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}