{"id":"W3080135677","doi":"10.1200/jco.2009.27.15_suppl.3510","title":"A phase I and pharmacological study of MK-1775, a Wee1 tyrosine kinase inhibitor, in both monotherapy and in combination with gemcitabine, cisplatin, or carboplatin in patients with advanced solid tumors","year":2009,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Gemcitabine; Tolerability; Neutropenia; Carboplatin; Internal medicine; Pharmacodynamics; Pharmacology; Oncology; Cancer; Pharmacokinetics; Cisplatin; Chemotherapy; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009956605,0.001676901,0.002051485,0.000607991,0.0004255057,0.00107397,0.0009425662,0.0011349,0.002477728],"category_scores_gemma":[0.00048853,0.0006593786,0.00156458,0.000547592,0.001122575,0.0008857449,0.0003435364,0.002836508,0.0007462394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001252245,"about_ca_system_score_gemma":0.002183954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001486465,"about_ca_topic_score_gemma":0.003384637,"domain_scores_codex":[0.9996421,0.0001224245,0.00001748879,0.00007878851,0.00004935531,0.00008984641],"domain_scores_gemma":[0.9995974,0.00003745659,0.00006146423,0.00003409024,0.00003260672,0.0002369695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4894466,0.1775837,0.006543977,0.001458903,0.001943934,0.0004811902,0.0005753084,0.004800132,0.1879985,0.00069681,0.005449863,0.1230211],"study_design_scores_gemma":[0.247405,0.7273962,0.009939434,0.00002860076,0.0005271924,0.000312465,0.00008922192,0.001314577,0.009159924,0.000187584,0.00360007,0.00003969528],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919198,0.002324555,0.0006720672,0.0003514945,0.0001230897,0.002315494,0.0008208294,0.00007126672,0.00140144],"genre_scores_gemma":[0.988152,0.002317771,0.001928328,0.0006792416,0.0001584473,0.002100656,0.00212141,0.00002886324,0.00251334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002477728,"threshold_uncertainty_score":0.009085715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03808350545614243,"score_gpt":0.4159918490186893,"score_spread":0.3779083435625469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}