{"id":"W3080146684","doi":"10.3389/fendo.2020.00529","title":"Corticotropin-Releasing Factor: An Ancient Peptide Family Related to the Secretin Peptide Superfamily","year":2020,"lang":"en","type":"article","venue":"Frontiers in Endocrinology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Scarborough Hospital; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; University of Toronto","keywords":"Secretin; SUPERFAMILY; Peptide; Secretin family; Biology; Internal medicine; Endocrinology; Medicine; Genetics; Biochemistry; Neuropeptide; Pancreas; Gene; Receptor; Vasoactive intestinal peptide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000120039,0.0002565777,0.0003317812,0.0003479447,0.0004024104,0.000551303,0.0003159432,0.0004104436,0.001135968],"category_scores_gemma":[0.0001656043,0.00009034429,0.0001551928,0.0004870883,0.0005372936,0.0004910034,0.0004435754,0.0004413268,0.0005675274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003178071,"about_ca_system_score_gemma":0.0003930684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007858475,"about_ca_topic_score_gemma":0.0007525858,"domain_scores_codex":[0.9999038,0.00000623335,0.000004458753,0.00004145416,0.00002593858,0.00001807489],"domain_scores_gemma":[0.9999382,0.00000499714,0.00002009889,0.000003290426,0.00001184622,0.00002151434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004108233,0.00005868163,0.01551599,0.002231262,0.0000891512,0.005377335,0.0008140785,0.0004987179,0.677048,0.01650855,0.004064663,0.2773828],"study_design_scores_gemma":[0.0001051101,0.0006233124,0.2237174,0.0006683217,0.0002177205,0.03271708,0.001118537,0.002570182,0.08022958,0.02173299,0.6361266,0.0001731425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.4255452,0.5072072,0.03274241,0.004608533,0.001169445,0.00009465624,0.001375622,0.0007514161,0.02650553],"genre_scores_gemma":[0.8212199,0.1507154,0.01238498,0.0008529632,0.000823175,0.00004795818,0.001036159,0.00004564708,0.01287375],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001135968,"threshold_uncertainty_score":0.003800213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01698037084808596,"score_gpt":0.2430881757850481,"score_spread":0.2261078049369622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}