{"id":"W3080203281","doi":"10.1021/acsmedchemlett.0c00223","title":"Insights into the Molecular Determinants Involved in Urocontrin and Urocontrin A Action","year":2020,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Allosteric regulation; Computational biology; Residue (chemistry); Function (biology); Peptide; Chemistry; Stereochemistry; Computer science; Biochemistry; Biology; Cell biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001841578,0.0002242622,0.0004230711,0.0000551556,0.00007912616,0.00003015788,0.0001860601,0.00008471026,0.00001984884],"category_scores_gemma":[0.000603156,0.0001604996,0.000115525,0.0003266004,0.0002936274,0.00008272469,0.0001268405,0.0006761595,0.000008414913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008314879,"about_ca_system_score_gemma":0.0000717564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001490036,"about_ca_topic_score_gemma":0.00002433797,"domain_scores_codex":[0.9981868,0.0001176613,0.0002973703,0.0004689406,0.0006110455,0.0003181925],"domain_scores_gemma":[0.9990902,0.0001478206,0.0000695217,0.0003219928,0.00006935648,0.0003010954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003678531,0.00002485353,0.005784708,0.0003337048,0.00008796687,0.002133225,0.001414415,0.000005521205,0.980963,0.000002806845,0.0002963741,0.008585601],"study_design_scores_gemma":[0.005285622,0.0001272836,0.02788724,0.0002907882,0.0001649087,0.0001485467,0.001420432,0.0003149805,0.9543767,0.00001955846,0.009703003,0.0002609656],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837157,0.002279368,0.0001138759,0.01306637,0.00003148883,0.0004252872,9.259467e-7,0.0000316395,0.000335376],"genre_scores_gemma":[0.992195,0.000484648,0.00002689521,0.006842006,0.0003371758,0.00005020407,0.00001089965,0.00002617747,0.0000270219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0265863,"threshold_uncertainty_score":0.6544985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02532701168202832,"score_gpt":0.2856300768453975,"score_spread":0.2603030651633692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}