{"id":"W3080203281","doi":"10.1021/acsmedchemlett.0c00223","title":"Insights into the Molecular Determinants Involved in Urocontrin and Urocontrin A Action","year":2020,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Allosteric regulation; Computational biology; Residue (chemistry); Function (biology); Peptide; Chemistry; Stereochemistry; Computer science; Biochemistry; Biology; Cell biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001829345,0.0002489499,0.0002145907,0.0000838879,0.0001166885,0.0002725252,0.0002960048,0.0003723247,0.001997256],"category_scores_gemma":[0.0001484152,0.00009150063,0.0001839017,0.00005302212,0.0003274725,0.0003650074,0.000197771,0.0006386662,0.0002346465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001840378,"about_ca_system_score_gemma":0.0001919487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001409049,"about_ca_topic_score_gemma":0.0001401169,"domain_scores_codex":[0.9999321,0.00001224499,0.00000487787,0.0000189188,0.00001575874,0.00001619888],"domain_scores_gemma":[0.9999158,0.00002461472,0.00002641747,0.000007094437,0.00000641631,0.00001956283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001625104,0.00003417294,0.0002689805,0.00007611352,0.000003873002,0.0002015918,0.00002223415,0.0002670482,0.9931546,0.001780042,0.00002684714,0.004001932],"study_design_scores_gemma":[0.00007960326,0.001348789,0.007262414,0.00003215434,0.00003003043,0.001667113,0.0001950015,0.007610672,0.9703858,0.002757359,0.008609719,0.00002129302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.969892,0.01007007,0.01357015,0.0006473948,0.00007431272,0.00006199072,0.00008109316,0.00008350264,0.005519398],"genre_scores_gemma":[0.9920867,0.002541,0.003881134,0.0002161368,0.00003299969,0.00002299978,0.00005953197,0.00000628935,0.00115324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001997256,"threshold_uncertainty_score":0.006681502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02532701168202832,"score_gpt":0.2856300768453975,"score_spread":0.2603030651633692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}