{"id":"W3080215993","doi":"10.1186/s13063-020-04651-1","title":"A pragmatic randomized controlled trial of multi-dose oral ondansetron for pediatric gastroenteritis (the DOSE-AGE study): statistical analysis plan","year":2020,"lang":"en","type":"article","venue":"Trials","topic":"Viral gastroenteritis research and epidemiology","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba; Centre Hospitalier Universitaire Sainte-Justine; Women and Children’s Health Research Institute; Institute for Clinical Evaluative Sciences; University of Ottawa; Institute of Health Economics; Children’s Health Research Institute; Stollery Children's Hospital; Alberta Children's Hospital; Children's Hospital of Western Ontario; Children's Hospital of Eastern Ontario; University of Calgary; Western University; University of Toronto; SickKids Foundation; Université de Montréal; Hospital for Sick Children","funders":"Institute of Population and Public Health; Canadian Institutes of Health Research; Children's Hospital Research Institute of Manitoba; Hospital for Sick Children; Alberta Children's Hospital Research Institute; Research Manitoba; CHEO Research Institute; Centre hospitalier universitaire Sainte-Justine; Women and Children's Health Research Institute; Alberta Children's Hospital Foundation; Kidscan Children's Cancer Research; Children's Health Research Institute; Children's Hospital Foundation","keywords":"Ondansetron; Medicine; Vomiting; Placebo; Emergency department; Adverse effect; Acute gastroenteritis; Dosing; Randomized controlled trial; Diarrhea; Nausea; Pediatrics; Oral rehydration therapy; Anesthesia; Population; Internal medicine; Alternative medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01934843,0.003907922,0.008195798,0.001243178,0.001004107,0.002135245,0.001938175,0.004763835,0.0173537],"category_scores_gemma":[0.02864792,0.00150237,0.005654391,0.0009956259,0.002559243,0.003465481,0.001693539,0.005181313,0.001188411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00180711,"about_ca_system_score_gemma":0.003886904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007882805,"about_ca_topic_score_gemma":0.001135297,"domain_scores_codex":[0.9709555,0.02379001,0.001267008,0.001932502,0.001050006,0.001004956],"domain_scores_gemma":[0.9847481,0.008084174,0.003494057,0.001133583,0.0009836371,0.001556541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.989011,0.001974992,0.0002145044,0.0008486066,0.001812953,0.00002408532,0.00003281049,0.0003294528,0.0001821194,0.0003819396,0.000705016,0.004482568],"study_design_scores_gemma":[0.9838459,0.01330166,0.000238375,0.00006505514,0.0006355285,0.000009110265,0.00001389249,0.0008169341,0.00005891908,0.0005379062,0.0004635032,0.00001320751],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.5338506,0.0131302,0.02513338,0.01031806,0.01164145,0.3843876,0.006308551,0.001634376,0.01359579],"genre_scores_gemma":[0.5883127,0.001928849,0.0395546,0.007304543,0.001733873,0.3544765,0.001602383,0.0001039187,0.004982579],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.01934843,"threshold_uncertainty_score":0.1023255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1373524424171694,"score_gpt":0.4319633122727802,"score_spread":0.2946108698556109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}