{"id":"W3080218538","doi":"10.1016/j.ygyno.2020.05.045","title":"The effect of age on efficacy, safety and patient-centered outcomes with rucaparib: A post hoc exploratory analysis of ARIEL3, a phase 3, randomized, maintenance study in patients with recurrent ovarian carcinoma","year":2020,"lang":"en","type":"article","venue":"Gynecologic Oncology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University Health Network; Princess Margaret Cancer Centre","funders":"Iovance Biotherapeutics; Merck Sharp and Dohme; Bristol-Myers Squibb Canada; National Cancer Institute; AbbVie Deutschland; Janssen Research and Development; EMD Serono; Genentech; Yale University; PharmaMar; V Foundation for Cancer Research; Eisai; Takeda Oncology; ImmunoGen; Syndax Pharmaceuticals; Ajinomoto; Clovis Oncology; Ovarian Cancer Research Fund; Gateway Foundation; Janssen Biotech; Les Laboratories Pierre Fabre; Syneos Health; AstraZeneca; Novocure; National Institutes of Health; Regeneron Pharmaceuticals; Ludwig Institute for Cancer Research; Array BioPharma; F. Hoffmann-La Roche; AbbVie; Sanofi; Merck; Amgen; Pfizer","keywords":"Medicine; Post-hoc analysis; Oncology; Ovarian carcinoma; Ovarian cancer; Internal medicine; Post hoc; Exploratory analysis; Cancer; Data science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00873898,0.001463757,0.003307519,0.0004002106,0.0004340459,0.001223689,0.000983389,0.001029867,0.002869648],"category_scores_gemma":[0.005976677,0.0004782364,0.005118625,0.0004880094,0.001186297,0.001790344,0.0007087346,0.00360983,0.0003793571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007814178,"about_ca_system_score_gemma":0.001161418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006535084,"about_ca_topic_score_gemma":0.001351726,"domain_scores_codex":[0.9954771,0.003011427,0.0002012027,0.0004999726,0.0003057556,0.0005044747],"domain_scores_gemma":[0.9933674,0.003847686,0.001028295,0.0008113424,0.000270248,0.0006750594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.9644435,0.003549449,0.008181589,0.0001827827,0.005755901,0.00004137312,0.00006803299,0.0008918724,0.002310205,0.00006436623,0.0003418419,0.01416917],"study_design_scores_gemma":[0.3128859,0.5340819,0.1263614,0.00005598758,0.01456335,0.0001544028,0.0001957019,0.005278961,0.004386263,0.0005435595,0.001374328,0.0001183005],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975436,0.0009979026,0.0003027481,0.0001016313,0.00005362045,0.0001654497,0.0004220541,0.00002820772,0.0003846718],"genre_scores_gemma":[0.9978533,0.0002574053,0.0004282826,0.0001420805,0.00009866737,0.0002369376,0.0004769634,0.00001903247,0.0004873822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00873898,"threshold_uncertainty_score":0.04621667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01780124132181258,"score_gpt":0.2996623743024941,"score_spread":0.2818611329806816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}