{"id":"W3080218538","doi":"10.1016/j.ygyno.2020.05.045","title":"The effect of age on efficacy, safety and patient-centered outcomes with rucaparib: A post hoc exploratory analysis of ARIEL3, a phase 3, randomized, maintenance study in patients with recurrent ovarian carcinoma","year":2020,"lang":"en","type":"article","venue":"Gynecologic Oncology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University Health Network; Princess Margaret Cancer Centre","funders":"Iovance Biotherapeutics; Merck Sharp and Dohme; Bristol-Myers Squibb Canada; National Cancer Institute; AbbVie Deutschland; Janssen Research and Development; EMD Serono; Genentech; Yale University; PharmaMar; V Foundation for Cancer Research; Eisai; Takeda Oncology; ImmunoGen; Syndax Pharmaceuticals; Ajinomoto; Clovis Oncology; Ovarian Cancer Research Fund; Gateway Foundation; Janssen Biotech; Les Laboratories Pierre Fabre; Syneos Health; AstraZeneca; Novocure; National Institutes of Health; Regeneron Pharmaceuticals; Ludwig Institute for Cancer Research; Array BioPharma; F. Hoffmann-La Roche; AbbVie; Sanofi; Merck; Amgen; Pfizer","keywords":"Medicine; Post-hoc analysis; Oncology; Ovarian carcinoma; Ovarian cancer; Internal medicine; Post hoc; Exploratory analysis; Cancer; Data science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007619312,0.0002958821,0.002165181,0.0002391302,0.00007657072,0.000007418408,0.0001456727,0.0001117436,0.00003754451],"category_scores_gemma":[0.0009272122,0.0001473085,0.0001733842,0.0007165582,0.0005702798,0.00003466872,0.00006467545,0.0003138561,0.000001114937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002795134,"about_ca_system_score_gemma":0.0001756035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003961562,"about_ca_topic_score_gemma":0.0004602242,"domain_scores_codex":[0.9965884,0.001437853,0.0008460835,0.0004732003,0.0003430676,0.0003113639],"domain_scores_gemma":[0.9952666,0.003308326,0.0007119923,0.0003813165,0.0001888535,0.0001428669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5002081,0.002558219,0.4791204,0.00003173815,0.001541411,0.0001101561,0.003476429,0.00005752304,0.00002759908,0.00002752484,0.00002568481,0.01281518],"study_design_scores_gemma":[0.3661506,0.0943552,0.5369074,0.00004350785,0.001223396,0.000001174427,0.0009046944,0.00009498181,0.00006056009,0.00000257158,0.0001401512,0.0001157979],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941024,0.0001283006,0.0000388905,0.001143646,0.000110918,0.004215584,0.00008157898,0.00002197948,0.0001566949],"genre_scores_gemma":[0.9986793,0.00003841234,0.00008819161,0.0007843479,0.000008704726,0.000323948,0.00005539624,0.00001759075,0.000004135768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1340576,"threshold_uncertainty_score":0.6007066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01780124132181258,"score_gpt":0.2996623743024941,"score_spread":0.2818611329806816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}