{"id":"W3080290327","doi":"10.3390/cancers12092371","title":"Dual Inhibition of Autophagy and PI3K/AKT/MTOR Pathway as a Therapeutic Strategy in Head and Neck Squamous Cell Carcinoma","year":2020,"lang":"en","type":"article","venue":"Cancers","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Université de Montréal","keywords":"PI3K/AKT/mTOR pathway; Autophagy; Head and neck squamous-cell carcinoma; Cancer research; Protein kinase B; Biology; Chemistry; Medicine; Cell biology; Cancer; Signal transduction; Apoptosis; Head and neck cancer; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000402333,0.0001279263,0.0002488429,0.00004865469,0.0000248101,0.000008623054,0.00002314806,0.00007453072,0.0001164111],"category_scores_gemma":[0.000008941818,0.0001172478,0.00003524739,0.0001338867,0.00009822047,0.00006011715,0.00001437765,0.0001235279,0.000003922834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001177771,"about_ca_system_score_gemma":0.00047179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003819761,"about_ca_topic_score_gemma":0.00002544035,"domain_scores_codex":[0.9992632,0.00003044008,0.0001864098,0.0002312263,0.0001224133,0.0001663262],"domain_scores_gemma":[0.9996068,0.00002592438,0.00006037917,0.0001021008,0.0000265386,0.0001781819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006917501,0.0004158236,0.07016873,0.002776757,0.0001551426,0.002170717,0.02093739,0.0004318358,0.8366296,0.002754421,0.0008420853,0.05580002],"study_design_scores_gemma":[0.02152824,0.007069627,0.3641089,0.0002109038,0.0001784953,0.00007438303,0.003314974,0.004018769,0.5962941,0.00122402,0.001446671,0.0005308393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989113,0.00881453,0.000005896884,0.0002884415,0.00003618573,0.0002887219,0.00002112065,0.00002379759,0.00140834],"genre_scores_gemma":[0.9980369,0.0001397711,0.00001403877,0.001584804,0.00009475608,0.00001818914,0.00001219063,0.00001847615,0.00008087408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2939402,"threshold_uncertainty_score":0.4781229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02303442218408386,"score_gpt":0.268189673637944,"score_spread":0.2451552514538602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}