{"id":"W3080311637","doi":"10.3389/fneur.2020.00881","title":"Mitochondrial Mechanisms of LRRK2 G2019S Penetrance","year":2020,"lang":"en","type":"article","venue":"Frontiers in Neurology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fonds National de la Recherche Luxembourg; Deutsche Forschungsgemeinschaft; Joachim Herz Stiftung; Canadian Institutes of Health Research; Alexander von Humboldt-Stiftung","keywords":"Penetrance; LRRK2; Mitochondrial DNA; Biology; Genetics; Medicine; Neuroscience; Mutation; Phenotype; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003215683,0.000382519,0.0002988435,0.0006288026,0.00014061,0.0003021614,0.000255453,0.0004406136,0.001566625],"category_scores_gemma":[0.0003873114,0.0001232612,0.0001905018,0.0002317956,0.0003381156,0.0002524769,0.0003995485,0.0002738606,0.0002606689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002261317,"about_ca_system_score_gemma":0.0000943589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005465812,"about_ca_topic_score_gemma":0.0003771407,"domain_scores_codex":[0.9997601,0.00004335589,0.000027902,0.00005931103,0.00007020009,0.00003909996],"domain_scores_gemma":[0.9996927,0.00003612558,0.0001687373,0.0000222286,0.00002821949,0.000052019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008209784,0.00006731164,0.0211928,0.00008053084,0.000031239,0.002718962,0.0001456656,0.0001506316,0.969519,0.0002884383,0.0001087831,0.004875761],"study_design_scores_gemma":[0.0001174904,0.001823923,0.6135026,0.00006774501,0.0001071649,0.03295382,0.0005642847,0.002206923,0.3447516,0.001187185,0.002678672,0.00003865287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981624,0.0007293381,0.0004264334,0.00005464884,0.000004392107,0.00001247185,0.0001628176,0.00003011561,0.0004173263],"genre_scores_gemma":[0.9993382,0.0002025363,0.0001131735,0.00001340397,0.00000342803,0.000004404894,0.0001145694,0.000005235682,0.0002049388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001566625,"threshold_uncertainty_score":0.005240858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009284273455000188,"score_gpt":0.2095512233056404,"score_spread":0.2002669498506402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}