{"id":"W3080386471","doi":"10.1158/1538-7445.am2020-6417","title":"Abstract 6417: LY3410738, a novel inhibitor of mutant IDH1 is more effective than Ivosidenib and potentiates antileukemic activity of standard chemotherapy in preclinical models of acute myeloid leukemia (AML)","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Myeloid leukemia; Isocitrate dehydrogenase; IDH1; Cancer research; Cytarabine; Myeloid; Chemistry; Pharmacology; Mutant; Medicine; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001871853,0.0006792342,0.0006706773,0.0002929796,0.0001439547,0.0003556752,0.0004037784,0.0003969233,0.00374779],"category_scores_gemma":[0.0001003322,0.000154166,0.0002461465,0.0002086424,0.0002679129,0.000250043,0.0001301756,0.001199713,0.0006422866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004364644,"about_ca_system_score_gemma":0.0006049203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007540003,"about_ca_topic_score_gemma":0.001100339,"domain_scores_codex":[0.9998695,0.00002572843,0.00001122227,0.00002269998,0.00003540994,0.00003545289],"domain_scores_gemma":[0.999913,0.000009646134,0.00001954334,0.000007090101,0.00000767322,0.00004310323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003134919,0.001385583,0.0004929714,0.0002277891,0.0000529006,0.0001372816,0.00003717577,0.0006108751,0.9782713,0.0003736053,0.001378468,0.01389702],"study_design_scores_gemma":[0.001835173,0.01842327,0.004535629,0.00002876202,0.00009673036,0.0005530735,0.00003291609,0.001764288,0.9621113,0.00009833923,0.01050542,0.00001510506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908594,0.002966257,0.0009197339,0.0003603566,0.0001320787,0.0001556881,0.001151433,0.0002687869,0.003186253],"genre_scores_gemma":[0.98867,0.001781616,0.0018799,0.0001321813,0.00003478354,0.0001729157,0.002401125,0.00003537439,0.004892243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00374779,"threshold_uncertainty_score":0.0125376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06601102206621924,"score_gpt":0.4055704191617963,"score_spread":0.339559397095577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}